Department of Family Medicine, CHA Bundang Medical Centre, CHA University, Seongnam 13496, Korea.
Healthcare R&D Division, Theragen Bio Co. Ltd., Suwon 16229, Korea.
Nutrients. 2020 Sep 18;12(9):2856. doi: 10.3390/nu12092856.
The aim of this study was to investigate the longitudinal change in muscle mass over 10 years according to serum calcium levels and calcium intake. A total of 1497 men and 1845 women aged 50 years and older were included. Significant muscle loss (SML) was defined as a 5% or greater loss from baseline, while time-dependent development of SML was assessed according to quartiles for corrected calcium level and daily calcium intake using Cox regression models. The incidence of SML was 6.7 and 7.7 per 100-person-years among men and women, respectively. Groups with the lowest corrected calcium levels had more prominent SML than those with higher calcium levels, regardless of sex. The relationship between SML and calcium intake was significant only among women. The hazard ratio for SML per 1 mmol/L increase in corrected calcium level was 0.236 and 0.237 for men and women, respectively. In conclusion, low serum calcium levels may predict SML among adults aged ≥ 50 years, while low calcium intake may be a predictor for muscle loss among women. Therefore, encouraging dietary calcium intake among middle-aged and older adults for preservation of muscle mass should be considered.
本研究旨在探讨血清钙水平和钙摄入量对 10 年内肌肉量的纵向变化。共纳入了 1497 名男性和 1845 名 50 岁及以上的女性。显著肌肉损失（SML）定义为与基线相比损失 5%或更多，而使用 Cox 回归模型根据校正钙水平和每日钙摄入量的四分位数评估 SML 的时变发展。男性和女性中 SML 的发生率分别为每 100 人年 6.7 和 7.7 例。无论性别如何，校正钙水平最低的组与钙水平较高的组相比，SML 更为明显。SML 与钙摄入量之间的关系仅在女性中具有统计学意义。校正钙水平每增加 1mmol/L，SML 的风险比为男性和女性分别为 0.236 和 0.237。总之，血清钙水平低可能是 50 岁及以上成年人发生 SML 的预测因素，而钙摄入不足可能是女性肌肉丢失的预测因素。因此，应考虑鼓励中年及以上成年人摄入膳食钙以保持肌肉量。
