Association between Polygenic Risk Score and One-Year Outcomes Following As-Needed Aflibercept Therapy for Exudative Age-Related Macular Degeneration.

We investigated whether polygenic risk score (PRS) was associated with one-year outcome of as-needed aflibercept therapy for exudative age-related macular degeneration (AMD), including AMD ( = 129) and polypoidal choroidal vasculopathy ( = 132). A total of 261 patients were treated with as-needed intravitreal aflibercept injection (IAI) after three monthly IAIs and the completion of a one-year follow-up. One hundred and seventy-two healthy volunteers served as controls. Genotyping of A69S (rs10490924), I62V (rs800292), (rs429608), (rs2241394), (rs6795735) and (rs3764261) was performed for all participants. A total of 63 PRSs were quantified. There was a positive association between the PRS involving , and best-corrected visual acuity at twelve months ( = 0.046, multiple regression analysis). When comparing PRSs of patients requiring retreatment and of patients without retreatment, 35 PRSs were significantly greater in patients requiring retreatment than in patients without requiring retreatment, with the PRS involving and being most significantly associated ( = 1.6 × 10). The number of additional injections was significantly associated with 40 PRSs and the PRS involving and showed a most significant -value ( = 2.42 × 10). Constructing a PRS using a combination with high-risk variants might be informative for predicting the response to IAI for exudative AMD.