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墨西哥女性宫颈样本中 HPV 基因型的流行率及其与临床因素的相关性。

Prevalence and correlation of human papillomavirus genotypes with clinical factors in cervical samples from Mexican women.

机构信息

Translational Medicine, Vanguard and Technology Transfer Sector, Human Health Department, Central ADN S.A. de C.V. Morelia, Michoacán 58090, México.

Biomedical Engineering Faculty, Anáhuac University, Querétaro 76246, México.

出版信息

Exp Biol Med (Maywood). 2021 Jan;246(1):48-56. doi: 10.1177/1535370220959747. Epub 2020 Sep 22.

Abstract

We are submitting data regarding the prevalence and type distribution of the HPV infection and the risk factors associated with it, which may provide a valuable reference to reinforce screening strategies, and to maintain HPV genotype surveillance in Mexico. We discuss the overall prevalence of HPV infection as detected in normal cytological samples stratified by age, different types of infection, and oncogenic capacity. One of the most important findings was that common HPV genotypes detected in healthy women were the genotype numbers: 6, 31, 16, and 56, likewise, smoking and having a history of more than three sexual partners over their lifetime, represented the main risk factors in this study. Furthermore, we found a low frequency of cytological abnormalities and CIN 1-3 in women with HR-HPV.

摘要

我们正在提交有关 HPV 感染的流行情况和类型分布以及相关危险因素的数据,这可能为加强筛查策略和维持墨西哥 HPV 基因型监测提供有价值的参考。我们讨论了在按年龄、不同感染类型和致癌能力分层的正常细胞学样本中检测到的 HPV 感染的总体流行情况。最重要的发现之一是,在健康女性中检测到的常见 HPV 基因型为基因型 6、31、16 和 56,同样,吸烟和一生中性伴侣超过三人的历史是本研究中的主要危险因素。此外,我们发现 HR-HPV 女性的细胞学异常和 CIN1-3 的发生率较低。

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