Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
BMC Infect Dis. 2020 Sep 22;20(1):698. doi: 10.1186/s12879-020-05419-3.
A new coronavirus disease 2019 (COVID-19) has escalated to a pandemic since its first outbreak in Wuhan, China. A small proportion of patients may have difficulty in generating IgM or IgG antibodies against SARS-CoV-2, and little attention has been paid to them.
We present two cases of confirmed COVID-19 patients and characterize their initial symptoms, chest CT results, medication, and laboratory test results in detail (including RT-PCR, IgM/ IgG, cytokine and blood cell counts).
Both of patients with confirmed COVID-19 pneumonia failed to produce either IgM or IgG even 40 to 50 days after their symptoms onset. This work provides evidence demonstrating that at least a small proportion of patients may have difficulty in rapidly gaining immunity against SARS-CoV-2.
自新型冠状病毒病 2019（COVID-19）首次在中国武汉爆发以来，已升级为大流行。一小部分患者可能难以产生针对 SARS-CoV-2 的 IgM 或 IgG 抗体，而对此类患者的关注较少。
我们介绍了两例确诊的 COVID-19 患者，并详细描述了他们的初始症状、胸部 CT 结果、用药情况和实验室检查结果（包括 RT-PCR、IgM/IgG、细胞因子和血细胞计数）。
两例确诊的 COVID-19 肺炎患者的 IgM 和 IgG 均未能产生，即使在症状出现后 40 至 50 天也是如此。这项工作提供了证据，证明至少有一小部分患者可能难以迅速获得针对 SARS-CoV-2 的免疫力。
