Rolle Teresa, Bonetti Beatrice, Mazzucco Alberto, Dallorto Laura
Eye Clinic, Department of Surgical Sciences, University of Torino, Via Cherasco 23, Torino, Italy.
BMC Ophthalmol. 2020 Sep 22;20(1):373. doi: 10.1186/s12886-020-01616-5.
The aim of the study is to evaluate the diagnostic ability of OCT parameters and retinal ganglion cells (RGCs) count in identify glaucomatous disease in myopic preperimetric eyes.
This was a cross-sectional observational study. The study group consisted of 154 eyes: 36 controls, 64 preperimetric (PPG), and 54 primary openangle glaucoma (POAG) eyes. Each group was divided into three subgroups based on axial length: emmetropic, myopic with axial length (AL) < 25 mm, and myopic with AL > 25 mm, to analyze the effect of myopia. The RGCs count was obtained using a model described later. As regard the influence of myopia on OCT parameters and RGC count, we performed Pearson's correlation. The Area Under Receiver Operator Characteristics Curves (AUROC curves) evaluated which parameter had the best sensitivity and specificity in identifying glaucoma in myopic eyes.
In Pearson's test, all Ganglion Cell Complex (GCC) thicknesses showed the weakest and less significant correlation with AL in all groups. All the AUROCs were statistically significant, and above 0.5. Inferior GCC and Global Loss Volume (GLV) showed the highest AUCs in all myopic group and the best diagnostic ability in distinguishing control from glaucomatous eyes. RGCcount showed good AUROC in all groups, with sensitivities of about 83% in myopic eyes, and specificity over 91% in all groups.
GCC is the parameter less influenced by the AL, and the inferior GCC and the GLV have the best diagnostic performance. The RGCcount has good sensitivity and specificity, so it can be used as a complementary test in the diagnosis of glaucoma in myopic preperimetric eyes.
本研究旨在评估光学相干断层扫描（OCT）参数和视网膜神经节细胞（RGCs）计数在识别近视性视野检查前期眼睛青光眼疾病中的诊断能力。
这是一项横断面观察性研究。研究组由154只眼睛组成：36只对照眼、64只视野检查前期（PPG）眼和54只原发性开角型青光眼（POAG）眼。根据眼轴长度将每组分为三个亚组：正视眼、眼轴长度（AL）<25mm的近视眼和AL>25mm的近视眼，以分析近视的影响。使用后文所述模型获得RGCs计数。关于近视对OCT参数和RGC计数的影响，我们进行了Pearson相关性分析。通过接受者操作特征曲线下面积（AUROC曲线）评估哪个参数在识别近视眼青光眼方面具有最佳的敏感性和特异性。
在Pearson检验中，所有组中所有神经节细胞复合体（GCC）厚度与AL的相关性最弱且不显著。所有AUROC均具有统计学意义且大于0.5。在所有近视组中，下方GCC和总体损失体积（GLV）显示出最高的AUC，并且在区分对照眼和青光眼眼中具有最佳诊断能力。RGC计数在所有组中均显示出良好的AUROC，近视眼的敏感性约为83%，所有组的特异性均超过91%。
GCC是受眼轴长度影响较小的参数，下方GCC和GLV具有最佳诊断性能。RGC计数具有良好的敏感性和特异性，因此可作为近视性视野检查前期眼睛青光眼诊断的补充检查。
