Faculty of Medicine, Ain Shams University, Cairo, Egypt; Online Research Club (www.onlineresearchclub.org).
Online Research Club (www.onlineresearchclub.org); Sulaiman Al Rajhi Colleges, College of Medicine, Saudi Arabia.
J Infect Public Health. 2020 Nov;13(11):1682-1693. doi: 10.1016/j.jiph.2020.08.010. Epub 2020 Sep 20.
The diagnosis of osteomyelitis is invasive and expensive as the current standard technique is the bone biopsy. Our aim was to compare the degree of agreement and concordance between standard bone biopsy and other non-bone techniques.
We performed an electronic search through 12 electronic databases to retrieve relevant studeis. Our criteria included any original article that reported the degree of agreement and/or the concordance between bone biopsy and other non-bone techniques in diagnosing osteomyelitis. We published our protocol in PROSPERO with a registration number, CRD42017080336.
There were 29 studies included in the qualitative analysis, of which 15 studies were included in the meta-analysis. Samples from sinus tract had the highest concordance with bone biopsy samples, while swab samples were the least concordant with bone biopsy samples. Additionally, Staphylococcus aureus was the most common bacteria isolated and the most concordant from samples, compared to other types of causative agents. Sinus tract had a significantly very high degree of agreement with bone samples. S. aureus had the highest degree of agreement in bone smaples.
Diagnosis of osteomyelitis using sinus tract swab is close in results' accuracy to bone biopsy. S. aureus was the most common extracted organism found in these samples and had the highest degree of agreement.
骨髓炎的诊断具有侵袭性和昂贵性，因为目前的标准技术是骨髓活检。我们的目的是比较标准的骨髓活检和其他非骨技术之间的一致性和符合程度。
我们通过 12 个电子数据库进行电子检索以检索相关研究。我们的标准包括任何报告骨髓活检与其他非骨技术在诊断骨髓炎方面的一致性和/或符合程度的原始文章。我们在 PROSPERO 中发布了我们的方案，注册编号为 CRD42017080336。
共有 29 项研究纳入定性分析，其中 15 项研究纳入荟萃分析。窦道样本与骨活检样本的一致性最高，而拭子样本与骨活检样本的一致性最低。此外，与其他类型的病原体相比，金黄色葡萄球菌是最常见的分离菌，与样本的一致性也最高。窦道与骨样本具有非常高的一致性。金黄色葡萄球菌在骨样片中具有最高的一致性。
使用窦道拭子诊断骨髓炎的结果准确性与骨髓活检接近。在这些样本中，金黄色葡萄球菌是最常见的提取菌，具有最高的一致性。
