Kahouli Sophia, Zahid Hafid, Khorassani Mohamed El, Kabbaj Saâd El, Benkirane Majid, Messaoudi Nezha
Laboratoire de Recherche et d´Analyses Médicales de la Fraternelle de la Gendarmerie Royale, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.
Service d´Hématologie-immunohématologie de l´Hôpital Militaire d´Instruction Mohammed V, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.
Pan Afr Med J. 2020 Jul 22;36:202. doi: 10.11604/pamj.2020.36.202.24477. eCollection 2020.
Erythrophagocytosis by blast cells is due to hyperactivation of blast cells. Erythrophagocytosis is associated with T cell myeloid hemopathies (8;16). This study shows an exceptional case of erythrophagocytosis by blast cells in a patient with acute T-lymphoblastic leukemia without cytogenetic abnormalities. We here report the case of A.Z, aged 19 years presenting with febrile syndrome with dizziness and phosphenes, tumor syndrome with amygdala and gingival hypertrophy. Blood count revealed hyperleukocytosis (399.5 G/L), with aregenerative anemia (Hb: 9.3 g/dl) and thrombocytopenia (platelet count: 40 g/L). Myelogram showed 90% of blast cells (MPO-negative) with erythrophagocytosis by blast cells images. Immunophenotyping confirmed T-cell LAL. Cytogenetic analysis was normal. Erythrophagocytosis by blast cells in patients with T-cell LAL appears to be a separate entity, hence the importance of images on diagnosis, prognosis and treatment of T-cell LAL.
原始细胞的红细胞吞噬作用是由于原始细胞的过度激活。红细胞吞噬作用与T细胞髓系血液病相关（8;16）。本研究展示了一例急性T淋巴细胞白血病患者中原始细胞的红细胞吞噬作用的特殊病例，该患者无细胞遗传学异常。我们在此报告19岁的A.Z的病例，其表现为伴有头晕和光幻视的发热综合征、伴有扁桃体和牙龈肥大的肿瘤综合征。血常规显示白细胞增多（399.5 G/L）、再生障碍性贫血（血红蛋白：9.3 g/dl）和血小板减少（血小板计数：40 g/L）。骨髓检查显示90%的原始细胞（髓过氧化物酶阴性）伴有原始细胞红细胞吞噬作用的图像。免疫表型分析证实为T细胞急性淋巴细胞白血病。细胞遗传学分析正常。T细胞急性淋巴细胞白血病患者中原始细胞的红细胞吞噬作用似乎是一个独立的实体，因此图像对于T细胞急性淋巴细胞白血病的诊断、预后和治疗具有重要意义。
