Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Oxid Med Cell Longev. 2020 Sep 4;2020:7289194. doi: 10.1155/2020/7289194. eCollection 2020.
Transient receptor potential (TRP) proteins consist of a superfamily of cation channels that have been involved in diverse physiological processes in the brain as well as in the pathogenesis of neurological disease. TRP channels are widely expressed in the brain, including neurons and glial cells, as well as in the cerebral vascular endothelium and smooth muscle. Members of this channel superfamily show a wide variety of mechanisms ranging from ligand binding to voltage, physical, and chemical stimuli, implying the promising therapeutic potential of TRP in neurological diseases. In this review, we focus on the physiological functions of TRP channels in the brain and the pathological roles in neurological disorders to explore future potential neuroprotective strategies.
瞬时受体电位 (TRP) 蛋白组成了一个阳离子通道超家族，它们参与了大脑中的多种生理过程以及神经疾病的发病机制。TRP 通道广泛表达于脑内，包括神经元和神经胶质细胞，以及脑血管内皮细胞和平滑肌。该通道超家族的成员表现出从配体结合到电压、物理和化学刺激等多种机制，这意味着 TRP 在神经疾病中具有有前途的治疗潜力。在这篇综述中，我们重点介绍了 TRP 通道在大脑中的生理功能以及在神经紊乱中的病理作用，以探索未来潜在的神经保护策略。
