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从栽培的 Griff. 中分离出的化学成分及其抗菌活性。

Chemicals Constituents Isolated from Cultivate Griff. and Antimicrobial Activity.

作者信息

Taib Mohamad Nurul Azmi Mohamad, Anuar Nursyazwani, Hanafiah Khayriyyah Mohd, Al-Shammary Aeman Ali Kudayr, Saaid Mardiana, Awang Khalijah

机构信息

School of Chemical Sciences, Universiti Sains Malaysia, 11800 USM Pulau Pinang, Malaysia.

School of Biological Sciences, Universiti Sains Malaysia, 11800 USM Pulau Pinang, Malaysia.

出版信息

Trop Life Sci Res. 2020 Apr;31(1):159-178. doi: 10.21315/tlsr2020.31.1.10. Epub 2020 Apr 7.

DOI:10.21315/tlsr2020.31.1.10
PMID:32963717
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7485532/
Abstract

Griff. is a plant species from the family Zingiberaceae. Coloquially known as wild ginger, Griff. is used as food condiment and for traditional treatment of skin diseases. Isolation studies to identify bioactive compounds of rhizomes of yielded seven compounds; 1'-1'-acetoxychavicol acetate (), --coumaryl diacetate (), -hydroxycinnamyl acetate (), 1'-1'-hydroxychavicol acetate () -hydroxybenzaldehyde (), stigmasterol () and -sitosterol (). Compounds , and were evaluated for antimicrobial activity against methicillin-resistant (MRSA). Among the compounds tested, Compound 1 showed good antimicrobial activity against the strain of MRSA with minimum inhibition concentration (MIC) value of 0.5 mg/mL. Meanwhile, Compounds and exhibited moderate activity with MIC value between 1.0 and 2.0 mg/mL. These findings indicate antimicrobial potential of 1'-1'-acetoxychavicol acetate (), compound derived from rhizome of Griff. against MRSA, which warrant further investigation.

摘要

Griff.是姜科的一种植物物种。通俗地称为野生姜，Griff.被用作食品调味料和用于传统治疗皮肤病。对其根茎的生物活性化合物进行的分离研究得到了七种化合物：1'-1'-乙酰氧基查维醇乙酸酯（）、--香豆酰二乙酸酯（）、-羟基肉桂酰乙酸酯（）、1'-1'-羟基查维醇乙酸酯（）、-羟基苯甲醛（）、豆甾醇（）和-谷甾醇（）。对化合物、和针对耐甲氧西林金黄色葡萄球菌（MRSA）的抗菌活性进行了评估。在所测试的化合物中，化合物1对MRSA菌株表现出良好的抗菌活性，最低抑菌浓度（MIC）值为0.5mg/mL。同时，化合物和表现出中等活性，MIC值在1.0至2.0mg/mL之间。这些发现表明源自Griff.根茎的1'-1'-乙酰氧基查维醇乙酸酯（）对MRSA具有抗菌潜力，值得进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fdd/7485532/ce4df2fe78a1/TLSR-31-1-159-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fdd/7485532/3795651471de/TLSR-31-1-159-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fdd/7485532/fdd135ced1ce/TLSR-31-1-159-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fdd/7485532/ce519fcaba62/TLSR-31-1-159-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fdd/7485532/cc857958b52e/TLSR-31-1-159-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fdd/7485532/ce4df2fe78a1/TLSR-31-1-159-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fdd/7485532/3795651471de/TLSR-31-1-159-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fdd/7485532/fdd135ced1ce/TLSR-31-1-159-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fdd/7485532/ce519fcaba62/TLSR-31-1-159-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fdd/7485532/cc857958b52e/TLSR-31-1-159-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fdd/7485532/ce4df2fe78a1/TLSR-31-1-159-g005.jpg

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