Department of Periodontology, Dental Clinics, Dental School, University Medicine Greifswald, Fleischmannstrasse 42, 17475, Greifswald, Germany.
Department of Pharmacology of the Center of Drug Absorption and Transport (C_DAT), University Medicine Greifswald, Greifswald, Germany.
Clin Oral Investig. 2021 Feb;25(2):701-709. doi: 10.1007/s00784-020-03594-w. Epub 2020 Sep 22.
SLC22A4/5 single nucleotide polymorphisms (SNPs) have been reported to affect inflammatory diseases. We report the relationship of these polymorphisms with adiposity and tooth loss as elucidated in a 10-year follow-up study.
Participants of the Study of Health in Pomerania (SHIP, N = 4105) were genotyped for the polymorphisms c.1507C > T in SLC22A4 (rs1050152) and -207C > G in SLC22A5 (rs2631367) using allele-specific real-time PCR assays. A total of 1817 subjects, 934 female and 883 male aged 30-80 years, underwent follow-up 10 years later (SHIP-2) and were assessed for adiposity and tooth loss.
The frequencies of the rarer SLC22A4 TT and SLC22A5 CC alleles were 16.7% and 20.3%, respectively. In women, tooth loss was associated with genotype TT vs. CC with incidence rate ratio IRR = 0.74 (95%C.I. 0.60-0.92) and CC vs. GG IRR = 0.79 (0.65-0.96) for SLC22A4 and SLC22A5 SNPs, respectively. In men, no such associations were observed. In the follow-up examination, the relationship between tooth loss and these SNPs was in parallel with measures of body shape such as BMI, body weight, waist circumference, or body fat accumulation. The association between muscle strength and body fat mass was modified by the genotypes studied.
SLC22A4 c.150C > T and SLC22A5 -207C > G polymorphisms are associated with tooth loss and markers of body shape in women but not in men.
Tooth loss may be related to obesity beyond inflammatory mechanisms, conceivably with a genetic background.
SLC22A4/5 单核苷酸多态性（SNPs）已被报道会影响炎症性疾病。我们报告了这些多态性与肥胖和牙齿缺失之间的关系，这是在一项为期 10 年的随访研究中阐明的。
使用等位基因特异性实时 PCR 分析，对来自波罗的海健康研究（SHIP，N=4105）的参与者进行 SLC22A4 中的 c.1507C>T（rs1050152）和 SLC22A5 中的-207C>G（rs2631367）多态性的基因型分析。共有 1817 名年龄在 30-80 岁的受试者（934 名女性和 883 名男性）在 10 年后（SHIP-2）接受了随访，并评估了肥胖和牙齿缺失情况。
SLC22A4 TT 和 SLC22A5 CC 罕见等位基因的频率分别为 16.7%和 20.3%。在女性中，与基因型 TT 相比，CC 与牙齿缺失的发病率比（IRR）为 0.74（95%CI 0.60-0.92），与 SLC22A4 和 SLC22A5 SNPs 的 CC 与 GG 的 IRR 分别为 0.79（0.65-0.96）。在男性中，未观察到这种关联。在随访检查中，牙齿缺失与这些 SNPs 的关系与 BMI、体重、腰围或体脂积累等身体形态指标平行。肌肉力量与体脂质量之间的关系受研究基因型的影响。
SLC22A4 c.150C>T 和 SLC22A5-207C>G 多态性与女性的牙齿缺失和身体形态标志物有关，但与男性无关。
牙齿缺失可能与肥胖有关，而不仅仅是炎症机制，这可能与遗传背景有关。
