University of Poonch, Department of Chemistry, Rawalakot, Azad Kashmir, Pakistan.
University of Malakand, Department of Biochemistry, Chakdara, Pakistan.
Braz J Biol. 2021 Jul-Sep;81(3):737-740. doi: 10.1590/1519-6984.230628. Epub 2021 Aug 31.
Curcuma longa is an important dietary plant which possess several pharmacological activities, including antioxidant, antimicrobial, anti-inflamatory, anticancer and anti clotting etc. The aim of the present study was to determine the phenolic profile of Curcuma longa and in vitro antioxidant and antidiabetic activities. In HPLC chromatogram of Curcuma longa rhizome extract 15 phenolic compounds were identified namely Digalloyl-hexoside, Caffeic acid hexoside, Curdione, Coumaric, Caffeic acid, Sinapic acid, Qurecetin-3-D-galactoside, Casuarinin, Bisdemethoxycurcumin, Curcuminol, Demethoxycurcumin, and Isorhamnetin, Valoneic acid bilactone, Curcumin, Curcumin-O-glucuronide respectively. The ethanolic extract displayed an IC50 value of 37.1±0.3 µg/ml against alpha glucosidase. The IC50 value of DPPH radical scavenging activity was 27.2 ± 1.1 μg/mL. It is concluded that ethanolic extract of Curcuma long is rich source of curcumin and contain several important phenolics. The in vitro antioxidant and alpha glucosidase inhibitory effect of the plant justifies its popular use in traditional medicine.
姜黄是一种重要的食用植物，具有多种药理活性，包括抗氧化、抗菌、抗炎、抗癌和抗凝血等。本研究旨在确定姜黄的酚类成分，并研究其体外抗氧化和抗糖尿病活性。在姜黄根茎提取物的 HPLC 色谱图中，鉴定出 15 种酚类化合物，分别为双没食子酰基葡萄糖苷、咖啡酸己糖苷、莪术酮、肉桂酸、咖啡酸、芥子酸、槲皮素-3-D-半乳糖苷、澳洲茄边碱、双去甲氧基姜黄素、姜黄素醇、去甲氧基姜黄素和异鼠李素、巴豆酸双内酯、姜黄素和姜黄素-O-葡糖苷酸。该植物的乙醇提取物对α-葡萄糖苷酶的 IC50 值为 37.1±0.3 µg/ml。DPPH 自由基清除活性的 IC50 值为 27.2 ± 1.1 μg/mL。综上所述，姜黄的乙醇提取物是姜黄素的丰富来源，并且含有几种重要的酚类化合物。该植物具有体外抗氧化和α-葡萄糖苷酶抑制作用，这也解释了其在传统医学中的广泛应用。
