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2
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Effect of Dapagliflozin on Atrial Fibrillation in Patients With Type 2 Diabetes Mellitus: Insights From the DECLARE-TIMI 58 Trial.达格列净对 2 型糖尿病患者心房颤动的影响：来自 DECLARE-TIMI 58 试验的见解。
Circulation. 2020 Apr 14;141(15):1227-1234. doi: 10.1161/CIRCULATIONAHA.119.044183. Epub 2020 Jan 27.
2
9. Pharmacologic Approaches to Glycemic Treatment: .9. 血糖治疗的药物学方法： 。
Diabetes Care. 2020 Jan;43(Suppl 1):S98-S110. doi: 10.2337/dc20-S009.
3
2019 update to: Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).2019 年更新：2018 年版《2 型糖尿病患者高血糖管理：美国糖尿病协会（ADA）与欧洲糖尿病研究协会（EASD）共识报告》。
Diabetologia. 2020 Feb;63(2):221-228. doi: 10.1007/s00125-019-05039-w.
4
Empagliflozin, a sodium glucose co-transporter-2 inhibitor, alleviates atrial remodeling and improves mitochondrial function in high-fat diet/streptozotocin-induced diabetic rats.恩格列净，一种钠-葡萄糖协同转运蛋白 2 抑制剂，可减轻高糖高脂饮食/链脲佐菌素诱导的糖尿病大鼠的心房重构并改善线粒体功能。
Cardiovasc Diabetol. 2019 Nov 28;18(1):165. doi: 10.1186/s12933-019-0964-4.
5
Mechanism of electrical remodeling of atrial myocytes and its influence on susceptibility to atrial fibrillation in diabetic rats.心房肌细胞电重构的机制及其对糖尿病大鼠心房颤动易感性的影响。
Life Sci. 2019 Dec 15;239:116903. doi: 10.1016/j.lfs.2019.116903. Epub 2019 Oct 19.
6
Atrial Fibrillation and Diabetes Mellitus: JACC Review Topic of the Week.心房颤动与糖尿病：美国心脏病学会评论专题之周更
J Am Coll Cardiol. 2019 Aug 27;74(8):1107-1115. doi: 10.1016/j.jacc.2019.07.020.
7
Therapeutic potential of vitamin D in AGE/RAGE-related cardiovascular diseases.维生素 D 在 AGE/RAGE 相关心血管疾病中的治疗潜力。
Cell Mol Life Sci. 2019 Oct;76(20):4103-4115. doi: 10.1007/s00018-019-03204-3. Epub 2019 Jun 27.
8
Metformin regulates lipid metabolism in a canine model of atrial fibrillation through AMPK/PPAR-α/VLCAD pathway.二甲双胍通过 AMPK/PPAR-α/VLCAD 通路调节犬心房颤动模型中的脂质代谢。
Lipids Health Dis. 2019 May 10;18(1):109. doi: 10.1186/s12944-019-1059-7.
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Empagliflozin Ameliorates Adverse Left Ventricular Remodeling in Nondiabetic Heart Failure by Enhancing Myocardial Energetics.恩格列净通过增强心肌能量代谢改善非糖尿病心力衰竭的不良左心室重构。
J Am Coll Cardiol. 2019 Apr 23;73(15):1931-1944. doi: 10.1016/j.jacc.2019.01.056.
10
Empagliflozin Attenuates Myocardial Sodium and Calcium Dysregulation and Reverses Cardiac Remodeling in Streptozotocin-Induced Diabetic Rats.恩格列净可减轻链脲佐菌素诱导的糖尿病大鼠心肌钠钙失调并逆转心脏重构。
Int J Mol Sci. 2019 Apr 4;20(7):1680. doi: 10.3390/ijms20071680.

抗糖尿病药物对心房颤动风险的影响：来自临床证据和转化研究的机制见解。

Effect of antidiabetic drugs on the risk of atrial fibrillation: mechanistic insights from clinical evidence and translational studies.

机构信息

Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.

出版信息

Cell Mol Life Sci. 2021 Feb;78(3):923-934. doi: 10.1007/s00018-020-03648-y. Epub 2020 Sep 23.

DOI:10.1007/s00018-020-03648-y
PMID:32965513
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11072414/
Abstract

Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF), which is the most common sustained arrhythmia and is associated with substantial morbidity and mortality. Advanced glycation end product and its receptor activation, cardiac energy dysmetabolism, structural and electrical remodeling, and autonomic dysfunction are implicated in AF pathophysiology in diabetic hearts. Antidiabetic drugs have been demonstrated to possess therapeutic potential for AF. However, clinical investigations of AF in patients with DM have been scant and inconclusive. This article provides a comprehensive review of research findings on the association between DM and AF and critically analyzes the effect of different pharmacological classes of antidiabetic drugs on AF.

摘要

糖尿病（DM）是心房颤动（AF）的独立危险因素，AF 是最常见的持续性心律失常，与大量发病率和死亡率相关。晚期糖基化终产物及其受体激活、心脏能量代谢障碍、结构和电重构以及自主神经功能障碍与糖尿病心脏中的 AF 病理生理学有关。抗糖尿病药物已被证明对 AF 具有治疗潜力。然而，对 DM 患者 AF 的临床研究很少且尚无定论。本文全面回顾了 DM 和 AF 之间关联的研究结果，并批判性分析了不同类别的抗糖尿病药物对 AF 的影响。