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脂肪间充质干细胞种植于几丁聚糖支架用于心脏组织工程。

Adipose-derived mesenchymal stem cell seeded Atelocollagen scaffolds for cardiac tissue engineering.

机构信息

Nursing School, Xinxiang Medical University, Xinxiang, 453003, China.

Henan Medical Tissue Regeneration Key Laboratory, Xinxiang Medical University, Xinxiang, 453003, China.

出版信息

J Mater Sci Mater Med. 2020 Sep 23;31(10):83. doi: 10.1007/s10856-020-06425-2.

DOI:10.1007/s10856-020-06425-2
PMID:32965534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7511278/
Abstract

ADMSCs were isolated from subcutaneous adipose tissue, characterized and cultured in vitro. GFP-labeled ADMSCs can grow and proliferate well on the Atelocollagen scaffolds, and induced by 5-aza the cells can differentiate into cardio-like cells. 3D cultured ADMSCs on Atelocollagen scaffolds were transplanted into mice ischemia myocardium, and have good biocompatibility with host cardio tissue.

摘要

ADMSCs 从皮下脂肪组织中分离出来，经过体外鉴定和培养。GFP 标记的 ADMSCs 可以在 Atelocollagen 支架上良好地生长和增殖，并且在 5-aza 的诱导下可以分化为心型样细胞。在 Atelocollagen 支架上进行 3D 培养的 ADMSCs 被移植到小鼠缺血心肌中，与宿主心组织具有良好的生物相容性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69b2/7511278/0624061b1202/10856_2020_6425_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69b2/7511278/315bd724a281/10856_2020_6425_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69b2/7511278/51850ccfb4b4/10856_2020_6425_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69b2/7511278/5e16be2b258b/10856_2020_6425_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69b2/7511278/8d4dc17dfceb/10856_2020_6425_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69b2/7511278/0624061b1202/10856_2020_6425_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69b2/7511278/315bd724a281/10856_2020_6425_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69b2/7511278/51850ccfb4b4/10856_2020_6425_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69b2/7511278/5e16be2b258b/10856_2020_6425_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69b2/7511278/8d4dc17dfceb/10856_2020_6425_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69b2/7511278/0624061b1202/10856_2020_6425_Fig5_HTML.jpg

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Novel injectable gallium-based self-setting glass-alginate hydrogel composite for cardiovascular tissue engineering.新型可注射镓基自凝玻璃-藻酸盐水凝胶复合材料用于心血管组织工程。
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通过结合多种生物工程技术提高基于干细胞的治疗潜力。
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