National Engineering Research Center of Seafood, School of Food Science and Technology, Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China..
Department of Biomedical Defense, Faculty of Naval Medicine, Naval Medical University (Second Military Medical University), Shanghai 200433, China.
Food Funct. 2020 Sep 23;11(9):7415-7420. doi: 10.1039/d0fo02017f.
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the world at an unprecedented rate. In the present study, 4 marine sulfated polysaccharides were screened for their inhibitory activity against SARS-CoV-2, including sea cucumber sulfated polysaccharide (SCSP), fucoidan from brown algae, iota-carrageenan from red algae, and chondroitin sulfate C from sharks (CS). Of them, SCSP, fucoidan, and carrageenan showed significant antiviral activities at concentrations of 3.90-500 μg mL-1. SCSP exhibited the strongest inhibitory activity with IC50 of 9.10 μg mL-1. Furthermore, a test using pseudotype virus with S glycoprotein confirmed that SCSP could bind to the S glycoprotein to prevent SARS-CoV-2 host cell entry. The three antiviral polysaccharides could be employed to treat and prevent COVID-19.
由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起的 2019 年冠状病毒病（COVID-19）以空前的速度在全球范围内传播。在本研究中，筛选了 4 种海洋硫酸多糖以评估其对 SARS-CoV-2 的抑制活性，包括海参硫酸多糖（SCSP）、褐藻来源的褐藻胶、红藻来源的角叉菜胶和鲨鱼来源的硫酸软骨素 C（CS）。其中，SCSP、褐藻胶和角叉菜胶在 3.90-500 μg mL-1浓度下表现出显著的抗病毒活性。SCSP 表现出最强的抑制活性，IC50 为 9.10 μg mL-1。此外，使用带有 S 糖蛋白的假型病毒进行的测试证实，SCSP 可以与 S 糖蛋白结合，从而防止 SARS-CoV-2 进入宿主细胞。这三种抗病毒多糖可用于治疗和预防 COVID-19。
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