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Beyond recanalization - a call for action in acute stroke.

作者信息

Stoll Guido, Pham Mirko

机构信息

Department of Neurology, Würzburg University Hospital, Würzburg, Germany.

Department of Neuroradiology, Würzburg University Hospital, Würzburg, Germany.

出版信息

Nat Rev Neurol. 2020 Nov;16(11):591-592. doi: 10.1038/s41582-020-00417-0.

DOI:10.1038/s41582-020-00417-0
PMID:32968233
Abstract
摘要

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Beyond recanalization - a call for action in acute stroke.超越血管再通——急性卒中行动呼吁
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Predictors of poor clinical outcome despite complete reperfusion in acute ischemic stroke patients.尽管急性缺血性脑卒中患者实现了完全再灌注，但仍存在临床预后不良的预测因素。
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Elevated mean platelet volume is associated with poor outcome after mechanical thrombectomy.血小板平均体积升高与机械取栓后不良预后相关。
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White Matter Hyperintensity Volume and Outcome of Mechanical Thrombectomy With Stentriever in Acute Ischemic Stroke.急性缺血性卒中使用支架取栓器进行机械取栓时的白质高信号体积与预后
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Comparison of outcome and interventional complication rate in patients with acute stroke treated with mechanical thrombectomy with and without bridging thrombolysis.比较机械取栓治疗急性脑卒中患者与桥接溶栓治疗患者的结局和介入并发症发生率。
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[Pitfalls in mechanical recanalization].[机械再通的陷阱]
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Repeated mechanical thrombectomy in short-term large vessel occlusion recurrence: multicenter study and systematic review of the literature.短期内血管再闭塞行重复机械取栓：多中心研究及文献系统评价。
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Leukoaraiosis severity and outcomes after mechanical thrombectomy with stent-retriever devices in acute ischemic stroke.急性缺血性脑卒中应用支架取栓装置机械取栓后白质疏松严重程度与结局。
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Association between age and outcomes following thrombectomy for anterior circulation emergent large vessel occlusion is determined by degree of recanalisation.年龄与前循环大血管闭塞急诊取栓后结局的关系取决于再通程度。
J Neurointerv Surg. 2019 Feb;11(2):114-118. doi: 10.1136/neurintsurg-2018-013964. Epub 2018 Jun 1.

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Albumin for patients with acute large-vessel occlusive stroke undergoing endovascular therapy (ARISE): the protocol of a randomized double-blind trial.急性大血管闭塞性卒中血管内治疗患者使用白蛋白的研究（ARISE）：一项随机双盲试验方案
Front Neurol. 2025 Jul 18;16:1570184. doi: 10.3389/fneur.2025.1570184. eCollection 2025.
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A novel model of light-induced middle cerebral artery occlusion and recanalization in mice.一种小鼠光诱导大脑中动脉闭塞和再通的新型模型。
Commun Biol. 2025 Jul 28;8(1):1117. doi: 10.1038/s42003-025-08398-w.
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Ischemia/reperfusion injury in acute human and experimental stroke: focus on thrombo-inflammatory mechanisms and treatments.

本文引用的文献

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CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke.CD84 将 T 细胞与血小板活动联系起来，参与急性脑卒中的血栓性炎症。
Circ Res. 2020 Sep 25;127(8):1023-1035. doi: 10.1161/CIRCRESAHA.120.316655. Epub 2020 Jul 30.
急性人类及实验性中风中的缺血/再灌注损伤：聚焦于血栓炎症机制与治疗
Neurol Res Pract. 2024 Nov 25;6(1):57. doi: 10.1186/s42466-024-00355-y.
4
Acute ischemic STROKE - from laboratory to the Patient's BED (STROKELABED): A translational approach to reperfusion injury. Study Protocol.急性缺血性卒中——从实验室到患者病床（STROKELABED）：再灌注损伤的转化研究方法。研究方案。
Transl Neurosci. 2024 Jul 12;15(1):20220344. doi: 10.1515/tnsci-2022-0344. eCollection 2024 Jan 1.
5
Directional induction of neural stem cells, a new therapy for neurodegenerative diseases and ischemic stroke.神经干细胞的定向诱导，一种治疗神经退行性疾病和缺血性中风的新疗法。
Cell Death Discov. 2023 Jul 1;9(1):215. doi: 10.1038/s41420-023-01532-9.
6
Distinct Alterations in Oxygenation, Ion Composition and Acid-Base Balance in Cerebral Collaterals During Large-Vessel Occlusion Stroke.在大血管闭塞性中风期间，脑侧支中的氧合、离子组成和酸碱平衡存在明显改变。
Clin Neuroradiol. 2023 Dec;33(4):973-984. doi: 10.1007/s00062-023-01296-w. Epub 2023 Jun 7.
7
Blockade of Platelet Glycoprotein Ibα Augments Neuroprotection in Orai2-Deficient Mice during Middle Cerebral Artery Occlusion.血小板糖蛋白 Ibα 阻断增强 Orai2 缺陷型小鼠大脑中动脉闭塞期间的神经保护作用。
Int J Mol Sci. 2022 Aug 22;23(16):9496. doi: 10.3390/ijms23169496.
8
An intravascular perspective on hyper-acute neutrophil, T-cell and platelet responses: Similarities between human and experimental stroke.血管内视角下的超急性中性粒细胞、T 细胞和血小板反应：人类和实验性中风之间的相似性。
J Cereb Blood Flow Metab. 2022 Sep;42(9):1561-1567. doi: 10.1177/0271678X221105764. Epub 2022 Jun 8.
9
Translational Stroke Research Review: Using the Mouse to Model Human Futile Recanalization and Reperfusion Injury in Ischemic Brain Tissue.转化卒中研究综述：利用小鼠模型模拟缺血性脑组织中无效再通和再灌注损伤。
Cells. 2021 Nov 25;10(12):3308. doi: 10.3390/cells10123308.
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Neurology at the crossroads.神经医学的十字路口
Nat Rev Neurol. 2020 Nov;16(11):587. doi: 10.1038/s41582-020-00424-1.