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通过计算研究探索微小 RNA 作为腮腺炎病毒感染中的转录调控因子。

Exploration of microRNAs as transcriptional regulator in mumps virus infection through computational studies.

机构信息

The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.

Department of Biochemistry, University of Okara, Okara, Pakistan.

出版信息

Sci Rep. 2024 Aug 14;14(1):18850. doi: 10.1038/s41598-024-67717-z.

DOI:10.1038/s41598-024-67717-z
PMID:39143101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11324793/
Abstract

Mumps is a common childhood infection caused by the mumps virus (MuV). Aseptic meningitis and encephalitis are usual symptoms of mumps together with orchitis and oophoritis that can arise in males and females, respectively. We have used computational tools: RNA22, miRanda and psRNATarget to predict the microRNA-mRNA binding sites to find the putative microRNAs playing role in the host response to mumps virus infection. Our computational studies indicate that hsa-mir-3155a is most likely involved in mumps infection. This was further investigated by the prediction of binding sites of hsa-mir-3155a to the MuV genome. Additionally, structure prediction using MC-Fold and MC-Sym, respectively has been applied to predict the 3D structures of miRNA and mRNA. The miRNA-mRNA interaction profile between has been confirmed through molecular docking simulation studies. Taken together, the putative miRNA (hsa_miR_6794_5p) has been found to be most likely involved in the regulation of transcriptional activity in the MuV infection.

摘要

流行性腮腺炎是由腮腺炎病毒（MuV）引起的常见儿童感染。无菌性脑膜炎和脑炎是腮腺炎的常见症状，睾丸炎和卵巢炎分别可发生于男性和女性。我们使用了计算工具：RNA22、miRanda 和 psRNATarget 来预测 microRNA-mRNA 结合位点，以寻找可能在宿主对腮腺炎病毒感染反应中发挥作用的 microRNAs。我们的计算研究表明，hsa-mir-3155a 很可能参与了腮腺炎感染。这通过预测 hsa-mir-3155a 与 MuV 基因组的结合位点进一步得到了证实。此外，分别使用 MC-Fold 和 MC-Sym 进行结构预测，以预测 miRNA 和 mRNA 的 3D 结构。通过分子对接模拟研究证实了 miRNA-mRNA 相互作用谱。综上所述，推测的 miRNA（hsa_miR_6794_5p）很可能参与了 MuV 感染中转录活性的调节。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d74/11324793/29eb24bc35c6/41598_2024_67717_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d74/11324793/5493963c0123/41598_2024_67717_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d74/11324793/004e3a9a01c0/41598_2024_67717_Fig11_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d74/11324793/29eb24bc35c6/41598_2024_67717_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d74/11324793/5493963c0123/41598_2024_67717_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d74/11324793/cc1eeb90c9b5/41598_2024_67717_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d74/11324793/e31d3083eb49/41598_2024_67717_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d74/11324793/84c44aec7341/41598_2024_67717_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d74/11324793/b6e8a293f10c/41598_2024_67717_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d74/11324793/827bc56b2b16/41598_2024_67717_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d74/11324793/2761ff836a57/41598_2024_67717_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d74/11324793/055bab23baa1/41598_2024_67717_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d74/11324793/e5bcf265e4cf/41598_2024_67717_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d74/11324793/0eddccf15534/41598_2024_67717_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d74/11324793/004e3a9a01c0/41598_2024_67717_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d74/11324793/a518b8a90f6c/41598_2024_67717_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d74/11324793/29eb24bc35c6/41598_2024_67717_Fig13_HTML.jpg

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