Laser Research Centre, Faculty of Health Sciences, University of Johannesburg P.O. Box 17011, Doornfontein 2028, South Africa.
Int J Mol Sci. 2020 May 9;21(9):3358. doi: 10.3390/ijms21093358.
The application of porphyrins and their derivatives have been investigated extensively over the past years for phototherapy cancer treatment. Phototherapeutic Porphyrins have the ability to generate high levels of reactive oxygen with a low dark toxicity and these properties have made them robust photosensitizing agents. In recent years, Porphyrins have been combined with various nanomaterials in order to improve their bio-distribution. These combinations allow for nanoparticles to enhance photodynamic therapy (PDT) cancer treatment and adding additional nanotheranostics (photothermal therapy-PTT) as well as enhance photodiagnosis (PDD) to the reaction. This review examines various porphyrin-based inorganic nanoparticles developed for phototherapy nanotheranostic cancer treatment over the last three years (2017 to 2020). Furthermore, current challenges in the development and future perspectives of porphyrin-based nanomedicines for cancer treatment are also highlighted.
近年来，卟啉及其衍生物在光疗癌症治疗方面的应用得到了广泛的研究。光疗卟啉具有产生高水平活性氧的能力，而暗毒性低，这些特性使它们成为强大的光敏剂。近年来，卟啉已与各种纳米材料结合，以改善其生物分布。这些组合使纳米粒子能够增强光动力疗法（PDT）癌症治疗，并将额外的纳米治疗（光热疗法-PTT）以及增强光诊断（PDD）添加到反应中。本综述检查了过去三年（2017 年至 2020 年）为光疗纳米治疗癌症治疗而开发的各种基于卟啉的无机纳米粒子。此外，还强调了基于卟啉的纳米药物在癌症治疗方面的开发和未来展望方面的当前挑战。
