Clínica Optométrica - Foundation Lluís Alcanyís, University of Valencia, Valencia, Spain.
Optics and Visual Perception Group (GOPV). Department of Optics, Pharmacology and Anatomy, University of Alicante, Crta San Vicente del Raspeig s/n 03016. San Vicente del Raspeig, Alicante, Spain.
Graefes Arch Clin Exp Ophthalmol. 2021 Jan;259(1):157-164. doi: 10.1007/s00417-020-04948-6. Epub 2020 Sep 25.
To characterize the fixation and macular integrity of subjects with multiple sclerosis (MS) with and without previous optic neuritis (ON) using microperimetry (MP).
Fifty-five eyes of MS patients, subdivided into three groups (28 eyes without ON, 16 with previous ON, and 11 eyes with previous ON in the contralateral eye), and 43 healthy eyes were enrolled (January-November 2018). All cases were evaluated using the MAIA microperimeter (Centervue), analyzing the following parameters: average macular threshold (AT), fixation indexes (P1 and P2), bivariate contour ellipse area (BCEA) for 95% and 63% of points, and horizontal (H) and vertical (V) axes of the ellipse of fixation.
All MS groups showed a significant reduced AT compared with the control group (p < 0.001). This reduction was more representative (p < 0.001) in eyes with previous ON. No statistically significant differences were found between MS patients with and without previous ON (p > 0.05). Mean AT was correlated with the examination time in all three groups (between ρ = - 0.798 p < 0.001 and ρ = - 0.49 p < 0.001). Significant differences in fixation parameters were only found between control and MS with ON groups (p < 0.02). The ratio of the disease showed a significant correlation with fixation parameters in MS groups (p < 0.02), but not with AT.
In MS patients, macular sensitivity is altered, especially in eyes with previous ON. Likewise, a fixational instability is present in MS patients with ON, with more increase of the V axis of the fixation area than of the H. The ratio of the disease also affects the patient fixation pattern.
使用微视野计（MP）描述既往视神经炎（ON）和无既往 ON 的多发性硬化（MS）患者的固视和黄斑完整性。
纳入 2018 年 1 月至 11 月的 MS 患者 55 只眼（无 ON 28 只眼、既往 ON 16 只眼、对侧眼既往 ON 11 只眼）和 43 只健康眼。所有病例均采用 MAIA 微视野计（Centervue）进行评估，分析以下参数：平均黄斑阈值（AT）、固视指标（P1 和 P2）、95%和 63%点的双变量轮廓椭圆面积（BCEA）、椭圆固视的水平（H）和垂直（V）轴。
所有 MS 组的 AT 均明显低于对照组（p<0.001）。既往 ON 眼的这种降低更为明显（p<0.001）。MS 有既往 ON 眼与无既往 ON 眼之间无统计学差异（p>0.05）。在所有三组中，平均 AT 与检查时间呈显著相关（三组之间的 ρ 值分别为-0.798，p<0.001 和 ρ=-0.49，p<0.001）。仅在对照组和 MS 伴 ON 组之间发现固视参数存在显著差异（p<0.02）。MS 组中疾病比例与固视参数呈显著相关性（p<0.02），但与 AT 无关。
在 MS 患者中，黄斑敏感性发生改变，尤其是既往有 ON 的眼。同样，MS 伴 ON 患者存在固视不稳定，固视区 V 轴的增加大于 H 轴。疾病比例也会影响患者的固视模式。
