Department of Paediatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Department of Neonatology, Inner Mongolia People's Hospital, Hohhot, 010010, China.
Sci Rep. 2020 Sep 25;10(1):15792. doi: 10.1038/s41598-020-72635-x.
To compare gut microbiota of healthy infants that were exclusively breast-fed or formula-fed, we recruited 91 infants, who were assigned into three different groups and fed by breast milk (30 babies), formula A (30 babies) or formula B (31 babies) exclusively for more than 4 months after birth. Faecal bacterial composition was tested. Among different groups, α diversity was lower in breast-fed group than formula-fed groups in 40 days of age, but increased significantly in 6 months of age. The Bifidobacterium represented the most predominant genus and Enterobacteriaceae the second in all groups. In 40 days of age, Bifidobacterium and Bacteroides were significantly higher, while Streptococcus and Enterococcus were significantly lower in breast-fed group than they were in formula A-fed group. Lachnospiraceae was lower in breast-fed than formula B-fed group. Veillonella and Clostridioides were lower in breast-fed than formula-fed groups. In 3 months of age there were less Lachnospiraceae and Clostridioides in breast-fed group than formula-fed groups. There were also significant differences of microbiota between formula A-fed and formula B-fed groups. Those differences may have impacts on their long-term health.
为了比较纯母乳喂养和配方奶喂养的健康婴儿的肠道微生物群，我们招募了 91 名婴儿，将他们分为三组，分别用母乳（30 名婴儿）、配方 A（30 名婴儿）或配方 B（31 名婴儿）进行纯母乳喂养，时间超过 4 个月。检测粪便细菌组成。在不同组中，母乳喂养组在 40 天时的 α 多样性低于配方奶喂养组，但在 6 个月时显著增加。双歧杆菌是所有组中最主要的属，肠杆菌科是第二主要的属。在 40 天时，母乳喂养组的双歧杆菌和拟杆菌显著高于配方 A 喂养组，而链球菌和肠球菌则显著低于配方 A 喂养组。母乳喂养组的lachnospiraceae 低于配方 B 喂养组。与配方奶喂养组相比，母乳喂养组的韦荣球菌和梭菌属较少。3 个月大时，母乳喂养组的lachnospiraceae 和梭菌属比配方奶喂养组少。配方 A 喂养组和配方 B 喂养组之间的微生物群也存在显著差异。这些差异可能对他们的长期健康产生影响。
