Turk Psikiyatri Derg. 2020 Fall;31(3):151-158. doi: 10.5080/u25070.
Opioid use disorder (OpUD) is a biological and psychosocial disorder with limited treatment options. Addition of physical exercise to the pharmacological treatment has been proposed to be effective on reducing substance use and improving the quality of life. In this study we aimed to investigate the effects of a high-intensity interval training (HIIT) program on the serum levels of cortisol, insulin-like growth factor1 (IGF-1), interferon-gamma (IFN-γ), interleukin 17 (IL-17) and the clinical progress of inpatients with OpUD.
Our study enrolled 22 male inpatients diagnosed with OpUD on the basis of the DSM-5 criteria. Two groups of 11 individuals were formed as the exercise (EG) and the control (CG) groups. The EG conducted 5 sessions of a HIIT. Participant data were collected with Sociodemographic Questionnaire, the Addiction Profile Index (API), and the Barratt Impulsiveness Scale (BIS-11). Also, the Hamilton Depression Rating Scale (HAM-D), the Hamilton Anxiety Rating Scale (HAM-A) and the Substance Craving Scale (SCS) were used before and after the treatment program in order to evaluate the clinical progress. Blood samples were collected on the 5th and the 21st days for estimation of the serum cortisol, IGF-1, IFN-γ and the IL-17 levels.
Comparison of the pre- and the post- treatment performances of the two groups on the HAM-D, the HAM-A and the SCS indicated a significant drop in the respective scores of the EG. Also, a significant increase was observed in the post-treatment IGF-1 level of the EG as compared to the CG. No differences were observed between the cortisol, IFN-γ and IL-17 levels of the EG and the CG.
HIIT resulted in significant reduction in the symptoms of depression, anxiety and substance craving, and increased the serum IGF-1 levels. HIIT did not change serum cortisol, IFN-γ and IL-17 levels. We believe this research will contribute to the literature on the treatment of opioid depencence by emphasising the effects of HIIT on patients treated for OpUD.
阿片类使用障碍（OpUD）是一种具有生物和心理社会特征的障碍，其治疗选择有限。将体育锻炼加入到药理学治疗中已被提出可以有效减少物质使用并提高生活质量。在这项研究中，我们旨在调查高强度间歇训练（HIIT）方案对阿片类使用障碍住院患者的皮质醇、胰岛素样生长因子 1（IGF-1）、干扰素-γ（IFN-γ）、白细胞介素 17（IL-17）血清水平和临床进展的影响。
我们的研究纳入了 22 名根据 DSM-5 标准诊断为 OpUD 的男性住院患者。将他们分为两组，每组 11 人，分别为运动组（EG）和对照组（CG）。EG 进行了 5 次 HIIT。使用社会人口学问卷、成瘾特征指数（API）和巴瑞特冲动量表（BIS-11）收集参与者数据。此外，在治疗计划前后使用汉密尔顿抑郁评定量表（HAM-D）、汉密尔顿焦虑评定量表（HAM-A）和物质渴求量表（SCS）来评估临床进展。在第 5 天和第 21 天采集血液样本，以评估血清皮质醇、IGF-1、IFN-γ 和 IL-17 水平。
两组 HAM-D、HAM-A 和 SCS 的治疗前后表现比较表明，EG 的各分数均显著下降。此外，与 CG 相比，EG 的 IGF-1 水平在治疗后显著升高。EG 和 CG 的皮质醇、IFN-γ 和 IL-17 水平没有差异。
HIIT 显著降低了抑郁、焦虑和物质渴求症状，并增加了血清 IGF-1 水平。HIIT 并未改变血清皮质醇、IFN-γ 和 IL-17 水平。我们相信，这项研究将通过强调 HIIT 对接受 OpUD 治疗的患者的影响，为阿片类依赖治疗的文献做出贡献。
