Department of Psychiatry, University of Campania "L. Vanvitelli", Naples, Italy.
Department of Medicine, Surgery and Health Sciences, University of Trieste and Department of Mental Health, Azienda Sanitaria Universitaria Giuliano Isontina - ASUGI, Trieste, Italy.
Eur Psychiatry. 2020 Sep 28;63(1):e87. doi: 10.1192/j.eurpsy.2020.89.
The Coronavirus disease 2019 (COVID-19) pandemic is an unprecedented traumatic event influencing the healthcare, economic, and social welfare systems worldwide. In order to slow the infection rates, lockdown has been implemented almost everywhere. Italy, one of the countries most severely affected, entered the "lockdown" on March 8, 2020.
The COvid Mental hEalth Trial (COMET) network includes 10 Italian university sites and the National Institute of Health. The whole study has three different phases. The first phase includes an online survey conducted between March and May 2020 in the Italian population. Recruitment took place through email invitation letters, social media, mailing lists of universities, national medical associations, and associations of stakeholders (e.g., associations of users/carers). In order to evaluate the impact of lockdown on depressive, anxiety and stress symptoms, multivariate linear regression models were performed, weighted for the propensity score.
The final sample consisted of 20,720 participants. Among them, 12.4% of respondents (N = 2,555) reported severe or extremely severe levels of depressive symptoms, 17.6% (N = 3,627) of anxiety symptoms and 41.6% (N = 8,619) reported to feel at least moderately stressed by the situation at the DASS-21.According to the multivariate regression models, the depressive, anxiety and stress symptoms significantly worsened from the week April 9-15 to the week April 30 to May 4 (p < 0.0001). Moreover, female respondents and people with pre-existing mental health problems were at higher risk of developing severe depression and anxiety symptoms (p < 0.0001).
Although physical isolation and lockdown represent essential public health measures for containing the spread of the COVID-19 pandemic, they are a serious threat for mental health and well-being of the general population. As an integral part of COVID-19 response, mental health needs should be addressed.
2019 年冠状病毒病（COVID-19）大流行是一场史无前例的创伤性事件，影响着全球的医疗保健、经济和社会福利系统。为了减缓感染率，几乎各地都实施了封锁。意大利是受影响最严重的国家之一，于 2020 年 3 月 8 日进入“封锁”状态。
COvid 心理健康试验（COMET）网络包括 10 个意大利大学站点和国家卫生研究所。整个研究分为三个不同阶段。第一阶段包括 2020 年 3 月至 5 月期间在意大利人群中进行的在线调查。通过电子邮件邀请信、社交媒体、大学、国家医学协会和利益相关者协会（例如，用户/照顾者协会）的邮寄名单进行招募。为了评估封锁对抑郁、焦虑和压力症状的影响，我们对多元线性回归模型进行了分析，并对倾向评分进行了加权。
最终样本包括 20720 名参与者。其中，12.4%的受访者（N=2555）报告有严重或极其严重的抑郁症状，17.6%（N=3627）有焦虑症状，41.6%（N=8619）报告在 DASS-21 上对当前情况感到至少中度压力。根据多元回归模型，从 4 月 9 日至 15 日这一周到 4 月 30 日至 5 月 4 日这一周，抑郁、焦虑和压力症状明显恶化（p<0.0001）。此外，女性受访者和有先前存在的心理健康问题的人患严重抑郁和焦虑症状的风险更高（p<0.0001）。
尽管身体隔离和封锁是遏制 COVID-19 大流行传播的重要公共卫生措施，但它们对普通民众的心理健康和福祉构成了严重威胁。作为 COVID-19 应对措施的一个组成部分，应满足心理健康需求。
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