Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, China.
Insect Molecular Genetics and Biotechnology, Institute of Biosciences and Applications, National Centre for Scientific Research Demokritos, Athens, Greece.
Front Immunol. 2020 Sep 2;11:2030. doi: 10.3389/fimmu.2020.02030. eCollection 2020.
Antimicrobial peptides (AMPs) with antiviral activity (antiviral peptides: AVPs) have become a research hotspot and already show immense potential to become pharmaceutically available antiviral drugs. AVPs have exhibited huge potential in inhibiting viruses by targeting various stages of their life cycle. Insects are the most speciose group of animals that inhabit almost all ecosystems and habitats on the land and are a rich source of natural AMPs. However, insect AVP mining, functional research, and drug development are still in their infancy. This review aims to summarize the currently validated insect AVPs, explore potential new insect AVPs and to discuss their possible mechanism of synthesis and action, with a view to providing clues to unravel the mechanisms of insect antiviral immunity and to develop insect AVP-derived antiviral drugs.
具有抗病毒活性的抗菌肽（AMPs）（抗病毒肽：AVPs）已成为研究热点，并且已经显示出巨大的潜力成为具有药用价值的抗病毒药物。AVPs 通过针对病毒生命周期的各个阶段来抑制病毒，具有巨大的潜力。昆虫是动物中种类最多的群体，几乎栖息在陆地的所有生态系统和栖息地中，是天然 AMPs 的丰富来源。然而，昆虫 AVP 的挖掘、功能研究和药物开发仍处于起步阶段。本综述旨在总结目前已验证的昆虫 AVPs，探索潜在的新昆虫 AVPs，并讨论其可能的合成和作用机制，以期为揭示昆虫抗病毒免疫机制和开发昆虫 AVP 衍生的抗病毒药物提供线索。
