Yang Fei, Ma Yunqi
School of Pharmacy, Binzhou Medical University, Yantai, 264003, China.
Amino Acids. 2024 Dec 4;56(1):68. doi: 10.1007/s00726-024-03427-0.
Antimicrobial peptides (AMPs) have broad-spectrum antimicrobial activity, enabling them to rapidly detect and eliminate targets. In addition, many AMPs are natural peptides, making them promising candidates for therapeutic drugs. This review discusses the basic properties and mechanisms of action of AMPs, highlighting their ability to disrupt microbial membranes and modulate host immune responses. It also reviews the current state of research into using AMPs against various viral infections, focusing on their therapeutic potential against viruses that contribute to the global health crisis. Despite promising developments, therapies based on AMPs still face challenges such as stability, toxicity, and production costs. In this text, we will discuss these challenges and the latest technological advances aimed at overcoming them. The combination of nanotechnology and bioengineering approaches offers new ways to enhance the delivery, efficacy, and safety of AMPs. We emphasize the importance of further research to fully exploit the potential of AMPs in antiviral therapy, advocating a multifaceted approach that includes optimizing clinical use and exploring synergies with existing antiviral drugs.
抗菌肽（AMPs）具有广谱抗菌活性，使其能够快速检测并清除靶标。此外，许多抗菌肽是天然肽，这使其成为治疗药物的有前景的候选物。本综述讨论了抗菌肽的基本特性和作用机制，强调了它们破坏微生物膜和调节宿主免疫反应的能力。它还回顾了使用抗菌肽对抗各种病毒感染的研究现状，重点关注其对导致全球健康危机的病毒的治疗潜力。尽管有前景的进展，但基于抗菌肽的疗法仍面临稳定性、毒性和生产成本等挑战。在本文中，我们将讨论这些挑战以及旨在克服它们的最新技术进展。纳米技术和生物工程方法的结合提供了增强抗菌肽递送、疗效和安全性的新方法。我们强调进一步研究以充分发挥抗菌肽在抗病毒治疗中的潜力的重要性，倡导一种多方面的方法，包括优化临床应用和探索与现有抗病毒药物的协同作用。
