Laboratory of Antiviral Drug Discovery, Institute of Molecular Biology of NAS, 0014, Yerevan, Armenia.
Denovo Sciences CJSC, 0033, Yerevan, Armenia.
J Gen Virol. 2021 Sep;102(9). doi: 10.1099/jgv.0.001661.
Current antiviral drugs are limited because of their adverse side effects and increased rate of resistance. In recent decades, much scientific effort has been invested in the discovery of new synthetic and natural compounds with promising antiviral properties. Among this new generation of compounds, antimicrobial peptides with antiviral activity have been described and are attracting attention due to their mechanism of action and biological properties. To understand the potential of antiviral peptides (AVPs), we analyse the antiviral activity of well-known AVP families isolated from different natural sources, discuss their physical-chemical properties, and demonstrate how AVP databases can guide us to design synthetic AVPs with better therapeutic properties. All considerations in this sphere of antiviral therapy clearly demonstrate the remarkable contribution that AVPs may make in conquering old as well as newly emerging viruses that plague humanity.
由于其不良反应和耐药率增加，目前的抗病毒药物受到限制。近几十年来，科学家们投入了大量精力来发现具有有前景的抗病毒特性的新合成和天然化合物。在这新一代化合物中，具有抗病毒活性的抗菌肽已经被描述出来，并因其作用机制和生物学特性而引起关注。为了了解抗病毒肽 (AVP) 的潜力，我们分析了从不同天然来源分离得到的知名 AVP 家族的抗病毒活性，讨论了它们的理化性质，并展示了 AVP 数据库如何指导我们设计具有更好治疗特性的合成 AVP。在抗病毒治疗领域的所有考虑因素都清楚地表明，AVP 可能在攻克困扰人类的旧有和新出现的病毒方面做出显著贡献。
