Zhou Kun, Wu Beibei, Pan Hang, Paudyal Narayan, Jiang Jize, Zhang Le, Li Yan, Yue Min
Department of Veterinary Medicine & Institute of Veterinary Sciences, Zhejiang University College of Animal Sciences, Hangzhou, China.
Zhejiang Province Center for Disease Control and Prevention, Hangzhou, China.
Front Vet Sci. 2020 Sep 2;7:521. doi: 10.3389/fvets.2020.00521. eCollection 2020.
Brucellosis is one of the most significant zoonosis over the world, threatening both veterinary and human public health. However, few studies were focused on nationwide animal brucellosis and made association with human brucellosis. We conducted a bilingual literature search on or brucellosis in China on the two largest databases (China National Knowledge Infrastructure and PubMed) and conducted a systematic review. A total of 1,383 Chinese and 81 English publications, published between 1958 and 2018 were identified. From them, 357 publications presenting 692 datasets were subjected to the meta-analysis. The overall prevalence rate is 1.70% (95% CI: 1.66-1.74), with a declining (until the late 1990s) and rising trend (starting the early 2000s). Interestingly, the animal with highest prevalence rate is canine (8.35%, 95% CI: 7.21-9.50), and lowest in cattle (1.22%, 95% CI: 1.17-1.28). The prevalence of in animals was unequally distributed among the 24 examined regions in China. Brucellosis is a reemerging disease for both humans and animals in China. The observed data suggests that dogs and yaks are the leading reservoirs for , and the provinces with highest prevalence rates in animals are Hubei, Sichuan, Inner Mongolia, Fujian, and Guizhou. Accordingly targeted intervention policy should be implemented to break the transmission chain between animals and humans in China.
布鲁氏菌病是全球最重要的人畜共患病之一，对兽医和人类公共健康均构成威胁。然而，很少有研究关注全国范围内的动物布鲁氏菌病及其与人类布鲁氏菌病的关联。我们在中国最大的两个数据库（中国知网和PubMed）上对中国的布鲁氏菌病进行了双语文献检索，并进行了系统综述。共检索到1958年至2018年间发表的1383篇中文和81篇英文出版物。其中，357篇包含692个数据集的出版物被纳入荟萃分析。总体患病率为1.70%（95%置信区间：1.66 - 1.74），呈现出下降趋势（直到20世纪90年代末）和上升趋势（从21世纪初开始）。有趣的是，患病率最高的动物是犬类（8.35%，95%置信区间：7.21 - 9.50），最低的是牛（1.22%，95%置信区间：1.17 - 1.28）。中国24个被调查地区动物布鲁氏菌病的患病率分布不均。布鲁氏菌病在中国对人类和动物来说都是一种再度出现的疾病。观察数据表明，狗和牦牛是布鲁氏菌病的主要宿主，动物患病率最高的省份是湖北、四川、内蒙古、福建和贵州。因此，应实施有针对性的干预政策，以打破中国动物与人类之间的布鲁氏菌病传播链。
