Department of Biomedical Engineering, North Tehran Branch, Islamic Azad University, Tehran, Iran.
Department of Electrical and Computer Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Sci Rep. 2020 Sep 28;10(1):15907. doi: 10.1038/s41598-020-72961-0.
This study aimed to find a new CSF hydrodynamic index to assess Chiari type I malformation (CM-I) patients' conditions and examine the relationship of this new index with morphometric and volumetric changes in these patients and their clinical symptoms. To this end, 58 CM-I patients in four groups and 20 healthy subjects underwent PC-MRI. Ten morphometric and three volumetric parameters were calculated. The CSF hydrodynamic parameters were also analyzed through computational fluid dynamic (CFD) simulation. The maximum CSF pressure was identified as a new hydrodynamic parameter to assess the CM-I patients' conditions. This parameter was similar in patients with the same symptoms regardless of the group to which they belonged. The result showed a weak correlation between the maximum CSF pressure and the morphometric parameters in the patients. Among the volumetric parameters, PCF volume had the highest correlation with the maximum CSF pressure, which its value being higher in patients with CM-I/SM/scoliosis (R = 65.6%, P = 0.0022) than in the other patients. PCF volume was the more relevant volumetric parameter to assess the patients' symptoms. The values of PCF volume were greater in patients that headache symptom was more obvious than other symptoms, as compared to the other patients.
本研究旨在寻找新的 CSF 流动力学指标来评估 Chiari Ⅰ型畸形（CM-I）患者的病情，并研究该新指标与患者形态计量学和体积变化及其临床症状之间的关系。为此，我们对四组 58 例 CM-I 患者和 20 名健康受试者进行了 PC-MRI 检查。计算了 10 个形态计量学参数和 3 个体积参数。通过计算流体动力学（CFD）模拟分析了 CSF 流动力学参数。最大 CSF 压力被确定为评估 CM-I 患者病情的新的流动力学参数。无论患者属于哪个组，具有相同症状的患者的最大 CSF 压力参数相似。结果表明，最大 CSF 压力与患者的形态计量学参数之间存在弱相关性。在体积参数中，PCF 体积与最大 CSF 压力的相关性最高，在患有 CM-I/SM/脊柱侧凸的患者中（R=65.6%，P=0.0022）高于其他患者。PCF 体积是评估患者症状的更相关的体积参数。与其他患者相比，头痛症状更明显的患者的 PCF 体积值更大。
