Department of Phytochemistry, Faculty of Biomedical Sciences, Uttarakhand Ayurved University, Dehradun, India.
Research and Development Centre, Faculty of Biomedical Sciences, Uttarakhand Ayurved University, Dehradun, India.
Phytother Res. 2021 Mar;35(3):1218-1229. doi: 10.1002/ptr.6885. Epub 2020 Sep 28.
Diabetes mellitus is a growing public health concern and an increasing interest has been raised to search for new compounds with therapeutic effects on β-cells. There are chronic insulin resistance and loss of β-cell mass in the case of type-2 diabetes which covers about 90% of total diabetic patients. This work aims to critically review the protective and regenerative effects of various antidiabetic natural products on pancreatic β-cells. A thorough literature survey was conducted on the natural molecules and extracts having a protective, regenerative, and repairing effect on β-cells. The primary source of the literature was online scientific databases such as PubMed, Scopus, and Google Scholar. Besides, selected relevant textbooks were also consulted. Various natural molecules including berberine, curcumin, mangiferin, stevioside and capsaicin, and extracts obtained from the plants like Capsicum annum, Gymnema sylvestre, Stevia rebaudiana and Nymphaea stellate, were found to produce regenerative and anti-apoptosis effects on β-cells. These natural products were also found to increase insulin secretion by stimulating β-cells. The present review concluded that a large number of molecules and extracts, abundantly found in nature, possess antidiabetic effect via targeting β-cells. Further research is warranted to use these agents as a drug against diabetes.
糖尿病是一个日益严重的公共卫生问题，人们越来越关注寻找具有治疗β细胞作用的新化合物。2 型糖尿病患者约占总糖尿病患者的 90%，其特征为慢性胰岛素抵抗和β细胞数量减少。本研究旨在综述各种具有保护和再生作用的抗糖尿病天然产物对胰腺β细胞的影响。对具有保护、再生和修复β细胞作用的天然分子和提取物进行了全面的文献调查。文献的主要来源是在线科学数据库，如 PubMed、Scopus 和 Google Scholar。此外，还查阅了选定的相关教科书。从植物中获得的各种天然分子，包括小檗碱、姜黄素、芒果苷、甜菊糖苷和辣椒素，以及从辣椒、匙羹藤、甜叶菊和睡莲中提取的提取物，被发现对β细胞具有再生和抗细胞凋亡作用。这些天然产物还被发现通过刺激β细胞来增加胰岛素分泌。本综述得出的结论是，大量的分子和提取物在自然界中大量存在，通过靶向β细胞发挥抗糖尿病作用。有必要进一步研究这些药物作为治疗糖尿病的药物。
