Laoung-On Jiraporn, Anuduang Artorn, Saenjum Chalermpong, Rerkasem Kittipan, Srichairatanakool Somdet, Boonyapranai Kongsak, Ounjaijean Sakaewan
Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand.
Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Biology (Basel). 2025 May 29;14(6):627. doi: 10.3390/biology14060627.
Type 2 diabetes mellitus is a chronic metabolic disease related to obesity and high-calorie diets, which presents hyperglycemia and insulin resistance. The management of diabetes can cause a rise in financial burden and synthetic medications can have adverse effects. This study aims to investigate the anti-diabetic and antioxidant activity of SHE, CME, and SHE in diabetic rats.
Seventy-eight rats were randomly assigned to the following 13 groups (n = 6): N-DW, D-DW, D-M, D-S, D-C, D-F, D-SC, D-SF, D-SM, D-CM, D-FM, D-SCM, and D-SFM, for 8 weeks. Body weight, relative organ weight, blood glucose, insulin resistance, and plasma biomarkers related to diabetes were determined.
Diabetic rats had a significantly decreased body weight, RBC-GHS, liver-GHS, and RBC-SOD activity and a significantly increased relative organ weight, blood glucose levels, insulin levels, insulin resistance, HbA1C, TC, TG, LDL, plasma-MDA, and liver-MDA when compared to the N-DW group. However, plant supplementation and metformin improved diabetes-related parameters, especially the combination of CME or FCME with SHE and metformin, which showed the greatest potential for improving diabetic conditions. (4) Conclusions: The research indicates that CME or FCME conjugated with SHE and metformin demonstrates the greatest potential for enhancing diabetic conditions, confirming positive synergism. These findings suggest that the combination of CME or FCME with SHE and metformin may be effective for diabetic treatment.
2型糖尿病是一种与肥胖和高热量饮食相关的慢性代谢疾病，表现为高血糖和胰岛素抵抗。糖尿病的治疗会导致经济负担增加，并且合成药物可能有不良反应。本研究旨在调查SHE、CME和SHE对糖尿病大鼠的抗糖尿病和抗氧化活性。
78只大鼠被随机分为以下13组（每组n = 6）：N-DW、D-DW、D-M、D-S、D-C、D-F、D-SC、D-SF、D-SM、D-CM、D-FM、D-SCM和D-SFM，为期8周。测定体重、相对器官重量、血糖、胰岛素抵抗以及与糖尿病相关的血浆生物标志物。
与N-DW组相比，糖尿病大鼠的体重、红细胞谷胱甘肽过氧化物酶（RBC-GHS）、肝脏谷胱甘肽过氧化物酶（liver-GHS）和红细胞超氧化物歧化酶（RBC-SOD）活性显著降低，相对器官重量、血糖水平、胰岛素水平、胰岛素抵抗、糖化血红蛋白（HbA1C）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）、血浆丙二醛（plasma-MDA）和肝脏丙二醛（liver-MDA）显著升高。然而，植物补充剂和二甲双胍改善了与糖尿病相关的参数，尤其是CME或FCME与SHE和二甲双胍的组合，显示出改善糖尿病状况的最大潜力。（4）结论：研究表明，CME或FCME与SHE和二甲双胍结合显示出改善糖尿病状况的最大潜力，证实了积极的协同作用。这些发现表明，CME或FCME与SHE和二甲双胍的组合可能对糖尿病治疗有效。
