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单能质子束中电离室的蒙特卡罗模拟束流质量和扰动校正因子。

Monte Carlo simulated beam quality and perturbation correction factors for ionization chambers in monoenergetic proton beams.

作者信息

Kretschmer Jana, Dulkys Anna, Brodbek Leonie, Stelljes Tenzin Sonam, Looe Hui Khee, Poppe Björn

机构信息

University Clinic for Medical Radiation Physics, Medical Campus Pius Hospital, Carl-von-Ossietzky University, Oldenburg, Germany.

Department of Radiation Therapy, Helios Clinics Schwerin, Schwerin, Germany.

出版信息

Med Phys. 2020 Nov;47(11):5890-5905. doi: 10.1002/mp.14499. Epub 2020 Oct 14.

Abstract

PURPOSE

Beam quality correction factors provided in current codes of practice for proton beams are approximated using the water-to-air mass stopping power ratio and by assuming the proton beam quality related perturbation correction factors to be unity. The aim of this work is to use Monte Carlo simulations to calculate energy dependent beam quality and perturbation correction factors for a set of nine ionization chambers in proton beams.

METHODS

The Monte Carlo code EGSnrc was used to determine the ratio of the absorbed dose to water and the absorbed dose to the sensitive air volume of ionization chambers related to the reference photon beam quality ( Co). For proton beams, the quantity was simulated with GATE/Geant4 for five monoenergetic beam energies between 70 MeV and 250 MeV. The perturbation correction factors for the air cavity, chamber wall, chamber stem, central electrode, and displacement effect in proton radiation were investigated separately. Additionally, the correction factors of cylindrical chambers were investigated with and without consideration of the effective point of measurement.

RESULTS

The perturbation factors were shown to deviate from unity for the investigated chambers, contradicting the assumptions made in dosimetry protocols. The beam quality correction factors for both plane-parallel and cylindrical chambers positioned with the effective point of measurement at the measurement depth were constant within 0.8%. An increase of the beam quality correction factors determined for cylindrical ionization chambers placed with their reference point at the measurement depth with decreasing energy is attributed to the displacement perturbation correction factors , which were up to 1.045 ± 0.1% for the lowest energy and 1.005 ± 0.1% for the highest energy investigated. Besides , the largest perturbation was found for the chamber wall where the smallest determined was 0.981 ± 0.3%.

CONCLUSIONS

Beam quality correction factors applied in dosimetry with cylindrical chambers in monoenergetic proton beams strongly depend on the positioning method used. We found perturbation correction factors different from unity. Consequently, the approximation of ionization chamber perturbations in proton beams by the respective water-to-air mass stopping power ratio shall be revised.

摘要

目的

现行质子束实践规范中提供的射束质量校正因子是通过水与空气的质量阻止本领比并假设与质子束质量相关的扰动校正因子为1来近似得到的。本研究的目的是使用蒙特卡罗模拟来计算质子束中一组9个电离室的能量相关射束质量和扰动校正因子。

方法

使用蒙特卡罗代码EGSnrc确定与参考光子束质量(Co)相关的电离室对水的吸收剂量与对灵敏空气体积的吸收剂量之比。对于质子束,使用GATE/Geant4模拟了70 MeV至250 MeV之间的五种单能束能量下的该量。分别研究了质子辐射中空气腔、室壁、室杆、中心电极和位移效应的扰动校正因子。此外,研究了考虑和不考虑有效测量点时圆柱形电离室的校正因子。

结果

对于所研究的电离室,扰动因子显示出与1有偏差,这与剂量学协议中的假设相矛盾。对于平面平行电离室和圆柱形电离室,当有效测量点位于测量深度时,射束质量校正因子在0.8%以内是恒定的。对于参考点位于测量深度的圆柱形电离室,随着能量降低,其确定的射束质量校正因子增加,这归因于位移扰动校正因子,对于所研究的最低能量,该因子高达1.045±0.1%,对于最高能量为1.005±0.1%。除了位移扰动校正因子外,室壁的扰动最大,确定的最小扰动为0.981±0.3%。

结论

在单能质子束剂量学中应用于圆柱形电离室的射束质量校正因子强烈依赖于所使用的定位方法。我们发现扰动校正因子不同于1。因此,应修订用各自的水与空气的质量阻止本领比来近似质子束中电离室扰动的方法。

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