Meznerics Fanni Adél, Illés Kata, Dembrovszky Fanni, Fehérvári Péter, Kemény Lajos Vince, Kovács Kata Dorottya, Wikonkál Norbert Miklós, Csupor Dezső, Hegyi Péter, Bánvölgyi András
Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.
Centre for Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.
Biomedicines. 2022 Jul 29;10(8):1829. doi: 10.3390/biomedicines10081829.
Alopecia areata (AA) is a chronic autoimmune condition that can lead to a serious deterioration in patients' quality of life. The first line of treatment in patchy AA is triamcinolone acetonide (TrA); however, the efficacy of the treatment varies greatly. Our aim was to investigate the therapeutic effects of platelet-rich plasma (PRP) in the treatment of AA.
We performed a systematic literature search in four databases. Randomized clinical trials (RCT) reporting on patients with AA treated with PRP were included, comparing PRP with TrA or a placebo. The primary outcome was the Severity of Alopecia Tool (SALT) score.
Our systematic search provided a total of 2747 articles. We identified four studies eligible for quantitative analysis. The pooled mean differences from the four studies did not exhibit a significant difference in the mean change in the SALT score when PRP and TrA groups were compared (MD =-2.04, CI: -4.72-0.65; I = 80.4%, = 0.14).
PRP is a promising topical, steroid-free treatment modality in the therapy of AA. No significant difference was found between PRP and TrA treatment; however, further high-quality RCTs are needed to further assess the efficacy of PRP treatment and strengthen the quality of evidence.
斑秃（AA）是一种慢性自身免疫性疾病，可导致患者生活质量严重下降。局部斑秃的一线治疗药物是曲安奈德（TrA）；然而，治疗效果差异很大。我们的目的是研究富血小板血浆（PRP）治疗斑秃的疗效。
我们在四个数据库中进行了系统的文献检索。纳入了报告PRP治疗斑秃患者的随机临床试验（RCT），将PRP与TrA或安慰剂进行比较。主要结局指标是脱发严重程度工具（SALT）评分。
我们的系统检索共获得2747篇文章。我们确定了四项符合定量分析条件的研究。当比较PRP组和TrA组时，四项研究的合并平均差在SALT评分的平均变化方面未显示出显著差异（MD = -2.04，CI：-4.72 - 0.65；I² = 80.4%，P = 0.14）。
PRP是一种有前景的局部、无类固醇的斑秃治疗方式。PRP治疗与TrA治疗之间未发现显著差异；然而，需要进一步的高质量RCT来进一步评估PRP治疗的疗效并加强证据质量。
