Albalat Waleed, Ebrahim Howyda M
Faculty of Medicine, Department of Dermatology, Venereology and Andrology, Zagazig University, Zagazig, Egypt.
J Cosmet Dermatol. 2019 Oct;18(5):1456-1462. doi: 10.1111/jocd.12858. Epub 2019 May 10.
Alopecia areata (AA) is nonscarring patchy area of hair loss. Platelets rich plasma (PRP) promotes development of new hair follicles. Dermoscopy is a diagnostic tool that helps in evaluation of skin microstructures which are not visible to naked eye.
To evaluate safety and efficacy of (PRP) vs intralesional corticosteroid (ILCs) in treatment of AA.
This study was conducted on 80 patients of both sexes who had AA. Patients were classified into Group I treated by ILCs and group II treated by (PRP). Results were assessed by dermoscopic evaluation and by hair re-growth score (RGS) at (baseline), 2, 4, 6, 8, and 12 weeks. Patients were followed up for 6 months.
There was greater hair re-growth after treatment in both groups. In group I, (26) patients (65%) showed improvement >70% compared to 29 patients (72.5%) in group II. There was significant re-growth of pigmented hair and decrease in dystrophic hair (P < 0.001) by dermoscopic evaluation in both groups. The difference between both groups was insignificant (P = 0.57). At follow-up, two (5%) patients in group II had relapse compared to 10 (25%) patients in group I.
Platelets rich plasma is safe and promising therapeutic option in AA.
斑秃（AA）是一种非瘢痕性的斑片状脱发。富血小板血浆（PRP）可促进新毛囊的发育。皮肤镜是一种有助于评估肉眼不可见的皮肤微观结构的诊断工具。
评估富血小板血浆（PRP）与皮损内注射皮质类固醇（ILCs）治疗斑秃的安全性和有效性。
本研究对80例患有斑秃的男女患者进行。患者分为接受皮损内注射皮质类固醇治疗的I组和接受富血小板血浆治疗的II组。通过皮肤镜评估以及在基线、2周、4周、6周、8周和12周时的毛发再生评分（RGS）来评估结果。对患者进行6个月的随访。
两组治疗后均有更多毛发再生。I组中，26例（65%）患者改善率>70%，而II组为29例（72.5%）。通过皮肤镜评估，两组中色素性毛发均有显著再生，营养不良性毛发减少（P<0.001）。两组之间的差异无统计学意义（P=0.57）。在随访中，II组有2例（5%）患者复发，而I组有10例（25%）患者复发。
富血小板血浆在斑秃治疗中是一种安全且有前景的治疗选择。
