CINBIO, Universidade de Vigo, As Lagoas, Marcosende, 36310 Vigo, Spain.
Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares, Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Nano Lett. 2020 Oct 14;20(10):7068-7076. doi: 10.1021/acs.nanolett.0c02180. Epub 2020 Oct 1.
Major current challenges in nano-biotechnology and nano-biomedicine include the implementation of predesigned chemical reactions in biological environments. In this context, heterogeneous catalysis is emerging as a promising approach to extend the richness of organic chemistry onto the complex environments inherent to living systems. Herein we report the design and synthesis of hybrid heterogeneous catalysts capable of being remotely activated by near-infrared (NIR) light for the performance of selective photocatalytic chemical transformations in biological media. This strategy is based on the synergistic integration of Au and TiO nanoparticles within mesoporous hollow silica capsules, thus permitting an efficient hot-electron injection from the metal to the semiconductor within the interior of the capsule that leads to a confined production of reactive oxygen species. These hybrid materials can also work as smart NIR-responsive nanoreactors inside living mammalian cells, a cutting-edge advance toward the development of photoresponsive theranostic platforms.
纳米生物技术和纳米生物医学的当前主要挑战包括在生物环境中实施预定的化学反应。在这种情况下，多相催化作为一种有前途的方法出现，可将丰富的有机化学扩展到生命系统固有的复杂环境中。在此，我们报告了设计和合成混合多相催化剂的方法，该催化剂能够通过近红外（NIR）光远程激活，从而在生物介质中进行选择性光催化化学反应。该策略基于 Au 和 TiO2 纳米粒子在介孔中空硅胶囊内的协同集成，从而允许在胶囊内部从金属到半导体进行有效的热电子注入，从而导致活性氧物质的受限产生。这些混合材料也可以在活的哺乳动物细胞内作为智能近红外响应纳米反应器发挥作用，这是朝着开发光响应治疗平台迈出的前沿进展。
