Creative Research Initiative Center for Nanospace-confined Chemical Reactions (NCCR), and Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 37673, South Korea.
Nano Lett. 2020 Oct 14;20(10):6981-6988. doi: 10.1021/acs.nanolett.0c01507. Epub 2020 Jul 9.
Nanoreactors, in which the reactions are remotely controlled by magnetic fields, are potentially valuable in bioorthogonal chemistry for future applications. Here, we develop a silica-confined magnetothermia-induced nanoreactor (MAG-NER) by selectively growing Pd nanocrystals on a preinstalled iron-oxide core inside a hollow silica nanoshell. The growth is achieved by magnetic induction. The interfacial catalytic site is activated by stimulating localized magnetothermia, and nanocompartmentalization is realized by the size-selective porous silica. Therefore, MAG-NER can be conveniently used in complex biomedia and can even be internalized to living cells, realizing an on-demand, high-performance intramolecular carbocyclization reaction by remote operation without compromising the cell viability. This work opens avenues for the design of advanced nanoreactors that complement and augment the existing bioorthogonal chemical tools.
纳米反应器可以通过磁场远程控制反应，在生物正交化学中有很大的应用潜力。在这里，我们通过在中空硅纳米壳内预先安装的氧化铁核上选择性地生长钯纳米晶体，开发了一种磁热诱导纳米反应器（MAG-NER）。这种生长是通过磁感应实现的。界面催化位点通过刺激局部磁热来激活，纳米分隔通过尺寸选择性多孔硅来实现。因此，MAG-NER 可以方便地用于复杂的生物介质中，甚至可以被内化到活细胞中，通过远程操作实现按需、高性能的分子内环化反应，而不会影响细胞活力。这项工作为设计先进的纳米反应器开辟了道路，这些纳米反应器可以补充和增强现有的生物正交化学工具。
