Araújo Carlos R G, Astarita Carlo, D'Aquino Riccardo, Pelegrine André A
Instituto São Leopoldo Mandic, Department of Implant Dentistry, Faculdade São Leopoldo Mandic, Campinas 13045-755, Brazil.
Human Brain Wave Srl, corso Galileo Ferraris 63, 10128 Turin, Italy.
Materials (Basel). 2020 Sep 25;13(19):4284. doi: 10.3390/ma13194284.
The aim of this study was to investigate the effect of the use of autologous micrografts obtained by the Rigenera® Micrografting Technology and xenograft on critical size defects created in the calvaria of rats. Forty-eight rats were randomly divided into four groups for each of the two evaluation times (15 and 30 days) (n = 6). After general anesthesia, a 5-mm diameter bone defect was created in the calvaria of each animal. Each defect was filled with the following materials: blood clot, autologous bone graft, xenograft, and xenograft associated with autologous micrografts. Histomorphometric and histological analysis showed that the group that have received the Rigenera® processed autologous micrografts combined with the xenograft and the group that received autologous bone graft resulted in greater bone formation in both time points when compared with the use of the xenograft alone and blood clot.
本研究的目的是调查使用通过Rigenera®微移植技术获得的自体微移植和异种移植对大鼠颅骨上产生的临界尺寸骨缺损的影响。在两个评估时间点（15天和30天），将48只大鼠随机分为四组（每组n = 6）。全身麻醉后，在每只动物的颅骨上制造一个直径5毫米的骨缺损。每个缺损用以下材料填充：血凝块、自体骨移植、异种移植以及与自体微移植相关的异种移植。组织形态计量学和组织学分析表明，与单独使用异种移植和血凝块相比，接受Rigenera®处理的自体微移植与异种移植联合使用的组以及接受自体骨移植的组在两个时间点均导致更大的骨形成。
