Department of Epidemiology, School of Public Health, Ministry of Education Key Laboratory of Public Health Safety, Fudan University, Shanghai, China.
State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, China.
J Viral Hepat. 2018 Dec;25(12):1543-1554. doi: 10.1111/jvh.12938. Epub 2018 Jun 20.
Viral hepatitis is a major public health concern in China, but data on national epidemiological characteristics are lacking. We collected reporting incidence data on hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in China from 2004 to 2014. Empirical mode decomposition (EMD) was performed to accurately describe the reporting incidence trends of HBV and HCV. A mathematical model was used to estimate the relative change in incidence across provinces and age groups. Nationwide, a total of 916 426 hepatitis B cases and 39 381 hepatitis C cases were recorded in 2004; the reporting incidences of HBV and HCV were 70.50/100 000 and 3.03/100 000, respectively. The overall relative changes in HBV and HCV reporting incidences in China from 2004 to 2014 were 0.98 (95% CI 0.96-1.00, P = .082) and 1.16 (95% CI 1.12-1.20, P < .001), respectively. Thirteen provinces experienced decline in HBV reporting incidence. Most provinces exhibited an increasing trend in HCV reporting incidence. People aged ≤24 displayed a significant descending trend in HBV reporting incidence; people aged ≥55 exhibited a significant increasing trend. For HCV infection, the reporting incidence increased in all age groups except the 10-14 age group. In China, the majority of provinces have experienced decline or remained stable in HBV infection but show significant increases in HCV infection. Children and adolescents are well protected from HBV infection, while relatively higher increasing rates are found among older people. HCV is much more prevalent among older people, although its emergence has shifted to younger age groups.
病毒性肝炎是中国的一个主要公共卫生问题，但缺乏全国性的流行病学特征数据。我们收集了 2004 年至 2014 年中国乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染报告发病率数据。采用经验模态分解（EMD）准确描述 HBV 和 HCV 报告发病率趋势。使用数学模型估计各省和各年龄组发病率的相对变化。全国范围内，2004 年共记录了 916426 例乙型肝炎和 39381 例丙型肝炎病例，HBV 和 HCV 的报告发病率分别为 70.50/10 万和 3.03/10 万。2004 年至 2014 年，中国 HBV 和 HCV 报告发病率的总体相对变化分别为 0.98（95%置信区间 0.96-1.00，P=0.082）和 1.16（95%置信区间 1.12-1.20，P<0.001）。13 个省份 HBV 报告发病率下降。大多数省份 HCV 报告发病率呈上升趋势。≤24 岁人群 HBV 报告发病率呈显著下降趋势；≥55 岁人群 HBV 报告发病率呈显著上升趋势。对于 HCV 感染，除 10-14 岁年龄组外，所有年龄组的报告发病率均增加。在中国，大多数省份 HBV 感染呈下降或稳定趋势，但 HCV 感染显著增加。儿童和青少年很好地免受 HBV 感染，但老年人的感染率呈相对较高的上升趋势。HCV 在老年人中更为普遍，尽管其出现已转移到年轻年龄组。
