Dkhil Mohamed A, Diab Marwa S M, Aljawdah Hossam M A, Murshed Mutee, Hafiz Taghreed A, Al-Quraishy Saleh, Bauomy Amira A
Department of Zoology, College of Science, King Saud University, Saudi Arabia.
Department of Zoology and Entomology, Faculty of Science, Helwan University, Egypt.
Saudi J Biol Sci. 2020 Oct;27(10):2863-2867. doi: 10.1016/j.sjbs.2020.07.009. Epub 2020 Jul 10.
Nanoparticles are now widely used in various aspects of life, especially zinc oxide nanoparticles (ZnNPs) that used in mouth washing, cosmetics, sunscreens, toothpaste and root canal flings. This research aims to determine the impact of ZnNPs on healthy mice's brain tissue. ZnNPs have caused major changes in the brain monoamines (dopamine, norepinephrine and serotonin) and ions such as Ca, Na, K and Zn. Concerning the histological picture, administration of ZnNPs caused some histopathological impairment in brain tissue. In addition, ZnNPs reduced the level of glutathione and catalase in brain tissue, although an increase in the level of nitrite / nitrate and ROS was observed, while the level of malondialdhyde was not significantly altered. Moreover, ZnNPs induced DNA fragmentation in brain of mice. Collectively, the obtained results revealed that ZnNPs affected the brain levels of investigated monamines, ions, enzymatic and non-enzymatic antioxidants thus they may have potential influence on central nervous system.
纳米颗粒目前广泛应用于生活的各个方面，尤其是用于漱口水、化妆品、防晒霜、牙膏和根管冲洗液中的氧化锌纳米颗粒（ZnNPs）。本研究旨在确定ZnNPs对健康小鼠脑组织的影响。ZnNPs已导致大脑单胺类物质（多巴胺、去甲肾上腺素和5-羟色胺）以及钙、钠、钾和锌等离子发生重大变化。关于组织学图像，ZnNPs的给药导致脑组织出现一些组织病理学损伤。此外，ZnNPs降低了脑组织中谷胱甘肽和过氧化氢酶的水平，尽管观察到亚硝酸盐/硝酸盐和活性氧水平升高，而丙二醛水平没有显著改变。此外，ZnNPs诱导小鼠大脑中的DNA片段化。总体而言，所得结果表明ZnNPs影响了所研究的单胺类物质、离子、酶促和非酶促抗氧化剂的大脑水平，因此它们可能对中枢神经系统有潜在影响。
