Ye Mengling, Chen Ye
Division of Medical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Institute of Genetics, Zhejiang University and Department of Genetics, Zhejiang University School of Medicine, Hangzhou, China.
Comput Struct Biotechnol J. 2020 Sep 5;18:2373-2380. doi: 10.1016/j.csbj.2020.08.025. eCollection 2020.
The zebrafish () has emerged as a popular model organism in developmental biology and pharmacogenetics due to its attribute of pathway conservation. Coupled with the availability of robust genetic and transgenic tools, transparent embryos and rapid larval development, studies of zebrafish allow detailed cellular analysis of many dynamic processes. In recent decades, the cellular and molecular mechanisms involved in the process of gonad development have been the subject of intense research using zebrafish models. In this mini-review, we give a brief overview of these studies, and highlight the essential genes involved in sex determination and gonad development in zebrafish.
由于其通路保守性的特点，斑马鱼已成为发育生物学和药物遗传学中一种广受欢迎的模式生物。再加上强大的遗传和转基因工具、透明的胚胎以及快速的幼体发育，对斑马鱼的研究能够对许多动态过程进行详细的细胞分析。近几十年来，利用斑马鱼模型对性腺发育过程中涉及的细胞和分子机制进行了深入研究。在本综述中，我们简要概述了这些研究，并重点介绍了斑马鱼性别决定和性腺发育中涉及的关键基因。
