Tommy Thomas, Islam Andi A, Hatta Mochammad, Bukhari Agussalim
Department of Neurosurgery, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia.
Department of Neurosurgery, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia.
Ann Med Surg (Lond). 2020 Sep 20;59:106-109. doi: 10.1016/j.amsu.2020.09.025. eCollection 2020 Nov.
Human mobility group box 1 (HMGB1) is a novel biomolecular agent which has a major part in inflammation process. HMGB1 has been known to be a strong pro-inflammatory factor as damage associated molecular pattern (DAMP) which its interaction with its receptor, the receptor of advanced glycation end products (RAGE), will cause positive amplification of inflammation signalling pathway.Brain injury is one of the major contributors for disability and death which neuroinflammation has a major role in its pathogenesis and influencing its outcome. In neuroinflammation, it has been described that HMGB1 may have a pivotal role in the process.
The objective of this article is to review the role HMGB1 in brain injury and its immunomodulatory properties.
A comprehensive search of literature was conducted in PubMed (NIH), Scopus, EMBASE, and Google Scholar database using keyword combinations of the medical subject headings (MeSH) of "HMGB1" and "Brain Injury" and relevant reference lists were also manually searched. All relevant articles of any study design published from year 1990 till June 2020, were included and narratively discussed in this review.
Twenty-four articles were shortlisted and reviewed in this article. Through these articles, we synthesis information on the function and metabolism of HMGB1, immunomodulatory effect of HMGB1, clinical findings and other potential treatment involving HMGB1, and role of HMGB1 protein in brain injury.
HMGB1 has a strong pro-inflammation property which predominantly acts through RAGE pathways.Review registration number reviewregistry966 in www.researchregistry.com.
人迁移率组蛋白B1（HMGB1）是一种新型生物分子因子，在炎症过程中起主要作用。已知HMGB1作为损伤相关分子模式（DAMP）是一种强大的促炎因子，其与受体晚期糖基化终产物受体（RAGE）相互作用会导致炎症信号通路的正反馈放大。脑损伤是导致残疾和死亡的主要原因之一，神经炎症在其发病机制及影响预后方面起主要作用。在神经炎症中，已有描述表明HMGB1可能在此过程中起关键作用。
本文旨在综述HMGB1在脑损伤中的作用及其免疫调节特性。
在PubMed（美国国立医学图书馆）、Scopus、EMBASE和谷歌学术数据库中使用医学主题词（MeSH）“HMGB1”和“脑损伤”的关键词组合进行全面文献检索，并手动搜索相关参考文献列表。纳入并在本综述中叙述性讨论了1990年至2020年6月发表的任何研究设计的所有相关文章。
本文筛选并综述了24篇文章。通过这些文章，我们综合了关于HMGB1的功能和代谢、HMGB1的免疫调节作用、临床研究结果以及其他涉及HMGB1的潜在治疗方法，以及HMGB1蛋白在脑损伤中的作用等信息。
HMGB1具有很强的促炎特性，主要通过RAGE途径发挥作用。综述注册号：www.researchregistry.com上的reviewregistry966。
