Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee, Florida, USA.
Euromov, University of Montpellier, Montpellier, France.
J Am Geriatr Soc. 2021 Feb;69(2):381-388. doi: 10.1111/jgs.16852. Epub 2020 Sep 30.
BACKGROUND/OBJECTIVES: Motoric cognitive risk (MCR) syndrome is characterized by cognitive complaints and slow gait speed in the absence of dementia. Consistent evidence indicates that it predicts dementia and premature mortality. Less is known about its antecedents, particularly the role of psychological function. Purpose in life is an aspect of well-being that reflects a goal-oriented and -driven life that has been implicated in cognitive aging. We aimed to examine the cross-sectional association between purpose in life and MCR and to test the hypothesis that purpose is associated with a lower risk of new cases of MCR over an up to 12-year follow-up.
Cross-sectional and longitudinal multi-cohort design.
Health and Retirement Study (HRS) and the National Health and Aging Trends Study (NHATS).
A total of 6,785 individuals from the HRS and 5,665 from the NHATS.
Participants reported on their purpose in life and cognitive complaints and completed a walking speed assessment. Cognitive complaints and walking speed were assessed again up to 12 years later in HRS and up to 7 years later in NHATS.
Higher purpose in life was associated with a 33% lower risk of MCR concurrently (meta-analytic odds ratio = .75; 95% confidence interval [CI] = .62-.90; P = .002) and an about 26% lower risk of incident MCR longitudinally (meta-analytic hazard ratio = .77; 95% CI = .70-.84; P < .001). These associations were significant in each sample, were independent of sociodemographic covariates, and persisted after controlling for personality and health-related factors (depressive symptoms, physical activity, disease burden).
Purpose in life is associated with a lower risk of incident MCR, an association that was replicated in two independent samples. Purpose is a malleable aspect of psychological function that is a promising target of intervention for healthier cognitive aging.
背景/目的：运动认知风险（MCR）综合征的特征是认知主诉和步态缓慢，而无痴呆。一致的证据表明，它可预测痴呆和过早死亡。关于其前兆的了解较少，特别是心理功能的作用。生活目的是幸福感的一个方面，反映了有目标和有动力的生活，这与认知老化有关。我们旨在检验生活目的与 MCR 的横断面关联，并检验假设，即生活目的与较低的 MCR 新发病例风险相关，随访时间长达 12 年。
横断面和纵向多队列设计。
健康与退休研究（HRS）和国家健康与老龄化趋势研究（NHATS）。
共有来自 HRS 的 6785 人和来自 NHATS 的 5665 人。
参与者报告了他们的生活目的和认知主诉，并完成了步行速度评估。在 HRS 中，认知主诉和步行速度在最多 12 年内再次进行评估，在 NHATS 中，在最多 7 年内再次进行评估。
较高的生活目的与同时发生的 MCR 风险降低 33%相关（荟萃分析优势比=0.75；95%置信区间[CI]为 0.62-0.90；P=0.002），与发生 MCR 的风险降低 26%相关（荟萃分析风险比=0.77；95%CI为 0.70-0.84；P <0.001）。这些关联在每个样本中均具有统计学意义，独立于社会人口统计学协变量，并且在控制人格和与健康相关的因素（抑郁症状、身体活动、疾病负担）后仍然存在。
生活目的与发生 MCR 的风险降低相关，这一关联在两个独立的样本中得到了复制。目的是心理功能的一个可塑方面，是更健康的认知老化的有希望的干预靶点。
