Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Cells. 2020 Sep 29;9(10):2193. doi: 10.3390/cells9102193.
Stem cell science is among the fastest moving fields in biology, with many highly promising directions for translatability. To centralize and contextualize some of the latest developments, this Special Issue presents state-of-the-art research of adult stem cells, induced pluripotent stem cells (iPSCs), and embryonic stem cells as well as cancer stem cells. The studies we include describe efficient differentiation protocols of generation of chondrocytes, adipocytes, and neurons, maturation of iPSC-derived cardiomyocytes and neurons, dynamic characterization of iPSC-derived 3D cerebral organoids, CRISPR/Cas9 genome editing, and non-viral minicircle vector-based gene modification of stem cells. Different applications of stem cells in disease modeling are described as well. This volume also highlights the most recent developments and applications of stem cells in basic science research and disease treatments.
干细胞科学是生物学中发展最快的领域之一，具有许多具有转化前景的方向。为了集中和阐述最新的一些进展，本期特刊介绍了成人干细胞、诱导多能干细胞 (iPSC) 和胚胎干细胞以及癌症干细胞的最新研究。我们收录的研究描述了高效分化软骨细胞、脂肪细胞和神经元的方案，iPSC 衍生的心肌细胞和神经元的成熟，iPSC 衍生的 3D 脑类器官的动态特征，CRISPR/Cas9 基因组编辑以及基于非病毒微小环载体的干细胞基因修饰。本卷还介绍了干细胞在疾病建模中的不同应用。本期特刊还重点介绍了干细胞在基础科学研究和疾病治疗中的最新发展和应用。
