Belgian Health Care Knowledge Centre (KCE), Belgium.
Sciensano, Belgium.
Int J Technol Assess Health Care. 2020 Dec;36(6):569-578. doi: 10.1017/S0266462320000513. Epub 2020 Oct 2.
The objective of this study was to map the PI culture at KCE in the context of the development of organization-wide supported position statements about PI.
A nominal group technique was used to measure the PI culture at KCE. Arguments for and against PI and conditions for PI in different phases of the HTA process were collected. A literature review and interviews fed the draft position statements, for which support was assessed by means of a two-round Delphi process.
Arguments in favor of PI in HTA related to the relevance of the scope, expertise with data collection, bringing in fresh ideas for study design, access to survey participants, validation of data analyses, adherence to recommendations. Disadvantages and risks included the lack of scientific knowledge of involved patients, resources requirements, conflicts of interest, and heterogeneity within patient populations. Conditions for meaningful PI referred to measures mitigating the identified disadvantages. Eighteen position statements supported by KCE could be formulated.
The KCE culture seems predominantly positive toward PI, although attitudes vary between HTA researchers. KCE recognizes the potential value of PI in HTA, but considers the level of involvement to be contingent on the topic and phase in the HTA process.
本研究旨在绘制 KCE 中的 PI 文化图谱，以了解组织内支持关于 PI 的立场声明的发展情况。
采用名义群体技术来衡量 KCE 中的 PI 文化。收集了关于 PI 的正反论据以及在 HTA 过程不同阶段的 PI 的条件。文献回顾和访谈为立场声明草案提供了素材，通过两轮 Delphi 流程评估了对这些草案的支持情况。
支持 HTA 中 PI 的论点涉及到研究范围的相关性、数据收集方面的专业知识、为研究设计带来新的思路、获得调查参与者的机会、数据分析的验证以及对建议的遵守。缺点和风险包括对涉及患者的科学知识的缺乏、资源需求、利益冲突以及患者群体内部的异质性。有意义的 PI 的条件是指减轻已识别的缺点的措施。可以制定十八项 KCE 支持的立场声明。
尽管态度在 HTA 研究人员之间有所不同，但 KCE 的文化似乎对 PI 持积极态度。KCE 认识到 PI 在 HTA 中的潜在价值，但认为参与程度取决于主题和 HTA 过程的阶段。
