Department of Ophthalmology, Maryknoll Hospital, Busan, South Korea.
Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul, South Korea.
Eye (Lond). 2021 Jul;35(7):1967-1976. doi: 10.1038/s41433-020-01199-x. Epub 2020 Oct 1.
The association between retinal microvascular structure and glaucoma has been revealed in multiple studies using optical tomography angiography (OCTA), but limited information on the macular vessel density (mVD) in patients with glaucoma is available. In this study, we tried to identity the factors that affected macular VD (mVD) in glaucomatous eyes.
This retrospective cross-sectional study evaluated OCT and OCTA images from 92 eyes from 58 healthy subjects and 179 eyes from 103 glaucoma patients using the SD-OCT database from July 2017 to July 2018. Glaucomatous eyes were further divided into two groups according to history of disc haemorrhage (DH). Association between mVD and demographic characteristics, ganglion cell-inner plexiform layer (GCIPL) thickness, visual field mean deviation (MD) and systemic blood pressure was analysed in each group.
In both healthy and glaucomatous eyes, mVD was inversely associated with age (β = -0.035, P = 0.025; β = -0.039, P = 0.018). In the glaucomatous eyes, mVD was significantly decreased, as the MD value was worse (β = 0.109, P = 0.002). In glaucomatous eyes with DH, mVD decreased as blood pressure increased (β = -0.111, P = 0.003) CONCLUSIONS: Reduced mVD is more common in older individuals in both healthy and glaucomatous eyes, and correlates with functional deterioration than structural damage in glaucomatous eyes. In glaucomatous eyes with DH, high systemic BP is associated with a reduction in mVD. This may indicate that glaucoma patients with DH are more susceptible to vascular damage secondary to hypertension.
多项使用光学断层扫描血管造影术（OCTA）的研究揭示了视网膜微血管结构与青光眼之间的关联，但有关青光眼患者黄斑血管密度（mVD）的信息有限。在本研究中，我们试图确定影响青光眼眼黄斑血管密度（mVD）的因素。
本回顾性横断面研究评估了 2017 年 7 月至 2018 年 7 月 SD-OCT 数据库中 58 名健康受试者的 92 只眼和 103 名青光眼患者的 179 只眼的 OCT 和 OCTA 图像。根据视盘出血（DH）的病史，将青光眼眼进一步分为两组。分析各组 mVD 与人口统计学特征、节细胞内丛状层（GCIPL）厚度、视野平均偏差（MD）和全身血压之间的关系。
在健康眼和青光眼眼中，mVD 与年龄呈负相关（β=-0.035，P=0.025；β=-0.039，P=0.018）。在青光眼眼中，随着 MD 值变差，mVD 显著降低（β=0.109，P=0.002）。在有 DH 的青光眼眼中，mVD 随着血压升高而降低（β=-0.111，P=0.003）。
在健康眼和青光眼眼中，mVD 在年龄较大的个体中更为常见，并且与功能恶化相关，而与青光眼眼中的结构损伤相关。在有 DH 的青光眼眼中，较高的全身血压与 mVD 降低相关。这可能表明，有 DH 的青光眼患者更容易发生高血压引起的血管损伤。
