Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Department of Ophthalmology, National Health Insurance Service Ilsan Hospital, Gyeonggi-do, South Korea.
Jpn J Ophthalmol. 2020 Sep;64(5):524-532. doi: 10.1007/s10384-020-00757-w. Epub 2020 Jul 9.
To investigate factors associated with macular vessel density and to analyze their effects according to glaucoma stage.
Retrospective cross-sectional study.
A total of 72 healthy eyes and 147 open-angle glaucomatous eyes were studied. All eyes underwent optical coherence tomography and visual field examinations. Clinical variables were compared according to the glaucoma stage. Relationships between macular vessel density (mVD) and other variables were analyzed using linear regression and segmented analyses.
Age (P = 0.010) and signal strength (P < 0.001) were associated with macular vessel density in healthy eyes. In glaucomatous eyes, age, signal strength, ganglion cell-inner plexiform layer (GCIPL) thickness, and mean deviation (MD) correlated with macular vessel density (all P ≤ 0.005). When analyzed by glaucoma stage, age correlated with macular vessel density in early (P = 0.017 and all P ≤ 0.012, respectively) and moderate (P = 0.002 and all P ≤ 0.001, respectively) glaucoma. Conversely, GCIPL thickness was associated with macular vessel density (P = 0.004). According to segmented analysis between MD and mVD, the MD value at the change point for mVD was -17.92 dB, which was much lower than that for GCIPL thickness (-5.83 dB).
Signal strength was the most significant factor associated with macular vessel density in healthy and glaucomatous eyes. Other than signal strength, factors associated with macular vessel density of glaucomatous eyes vary according to the glaucoma stage. The segmented analysis suggests that mVD could be better than GCIPL thickness in predicting MD changes in moderate-to-advanced glaucoma.
探讨与黄斑血管密度相关的因素，并根据青光眼分期分析其影响。
回顾性横断面研究。
共纳入 72 只健康眼和 147 只开角型青光眼眼。所有眼均行光学相干断层扫描和视野检查。根据青光眼分期比较临床变量。采用线性回归和分段分析，分析黄斑血管密度（mVD）与其他变量之间的关系。
在健康眼中，年龄（P = 0.010）和信号强度（P < 0.001）与黄斑血管密度相关。在青光眼眼中，年龄、信号强度、神经节细胞-内丛状层（GCIPL）厚度和平均偏差（MD）与黄斑血管密度相关（均 P ≤ 0.005）。按青光眼分期分析时，年龄与早期（P = 0.017 和所有 P ≤ 0.012，分别）和中度（P = 0.002 和所有 P ≤ 0.001，分别）青光眼的黄斑血管密度相关。相反，GCIPL 厚度与黄斑血管密度相关（P = 0.004）。根据 MD 和 mVD 之间的分段分析，mVD 变化点的 MD 值为-17.92 dB，明显低于 GCIPL 厚度（-5.83 dB）。
信号强度是健康眼和青光眼眼中与黄斑血管密度最显著相关的因素。除信号强度外，青光眼眼黄斑血管密度的相关因素因青光眼分期而异。分段分析表明，mVD 可能比 GCIPL 厚度更能预测中重度青光眼的 MD 变化。
