两种红树林植物在链脲佐菌素诱导的糖尿病动物模型中的降血糖和降血脂作用
Hypoglycemic and hypolipidemic effects of two mangrove plants in a streptozotocin-induced animal model of diabetes.
作者信息
Zeid Isam ELDin Mohamed ELAmin Abu, Jaghthmi Obidallah Hamdan Ali Al
机构信息
Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudia Arabia.
出版信息
J Adv Vet Anim Res. 2020 Aug 3;7(3):421-428. doi: 10.5455/javar.2020.g437. eCollection 2020 Sep.
OBJECTIVE
This study aims at evaluating the anti-diabetic, hypolipidemic, and pancreatic histopathological changes of and .
MATERIALS AND METHODS
The experimental rats were divided into eight groups ( = 15 each). Streptozotocin was used to induce diabetes. Daily oral administration of an aqueous extract from the leaves of and at 400 mg/kg BW, and a mixture of the two extracts for 6 weeks was assessed. The measurements of serum glucose, insulin, and lipid profile were carried out. Pancreatic specimens were collected from all groups and processed for pathological studies.
RESULTS
The study revealed that the plant extracts restored the levels of diabetic markers and lipid profiles of diabetic rats, with no significant changes in non-diabetic ones. The extract of exhibited more promising anti-diabetic and hypolipidemic effects than singly or combined.
CONCLUSION
Leaf extracts from , singly or combined, and , induced a potent anti-diabetic and hypolipidemic potential in diabetic rats.
目的
本研究旨在评估[植物名称1]和[植物名称2]的抗糖尿病、降血脂作用以及胰腺组织病理学变化。
材料与方法
将实验大鼠分为八组（每组n = 15）。使用链脲佐菌素诱导糖尿病。评估每日口服400 mg/kg体重的[植物名称1]叶水提取物、[植物名称2]叶水提取物以及两种提取物的混合物，持续6周。进行血清葡萄糖、胰岛素和血脂谱的测量。从所有组收集胰腺标本并进行病理研究。
结果
研究表明，植物提取物恢复了糖尿病大鼠的糖尿病标志物水平和血脂谱，非糖尿病大鼠无显著变化。[植物名称1]提取物单独或联合使用时，比[植物名称2]表现出更有前景的抗糖尿病和降血脂作用。
结论
[植物名称1]叶提取物单独或联合[植物名称2]叶提取物，在糖尿病大鼠中诱导出强大的抗糖尿病和降血脂潜力。
Zotero 插件