• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

间充质干细胞减轻犬特应性皮炎。

Canine atopic dermatitis attenuated by mesenchymal stem cells.

作者信息

de Oliveira Ramos Fernanda, Malard Patricia Furtado, Brunel Hilana Dos Santos Sena, Paludo Giane Regina, de Castro Marcio Botelho, da Silva Paulo Henrique Sampaio, da Cunha Barreto-Vianna Andre Rodrigues

机构信息

Department of Dermatology, Pet Especialidades Centro Veterinário, Brasilia, Brazil.

Biocell Laboratory Celular Therapy, Brasilia, Brazil.

出版信息

J Adv Vet Anim Res. 2020 Sep 1;7(3):554-565. doi: 10.5455/javar.2020.g453. eCollection 2020 Sep.

DOI:10.5455/javar.2020.g453
PMID:33005683
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7521806/
Abstract

OBJECTIVE

To evaluate the use of mesenchymal stem cells (MSCs) in the attenuation of canine atopic dermatitis (AD).

MATERIALS AND METHODS

Sixteen dogs were selected and divided into three groups, mild, moderate, and severe, according to the Canine Atopic Dermatitis Extent and Severity Index (CADESI-4). They were evaluated for 82 days. The protocol recommended in this experiment was to inject 2 × 10/kg bodyweight of MSC's in all groups by the intravenous route with intervals of applications of 21 days. The degree of pruritus was evaluated by examining the visual analog scale, the CADESI-4, the histopathology of the skin, hematological and biochemical parameters, the pyogenic effect of MSCs, and the thickness of the epidermis.

RESULTS

There was a significant difference in the reduction of epidermal thickness in the moderate and severe groups. Hematological, biochemical, and body temperature parameters remained within normal limits for the species with no side effects.

CONCLUSION

MSCs attenuated the clinical signs of AD.

摘要

目的

评估间充质干细胞（MSCs）在减轻犬特应性皮炎（AD）中的应用。

材料与方法

根据犬特应性皮炎范围和严重程度指数（CADESI-4）选择16只犬，并分为轻度、中度和重度三组。对它们进行了82天的评估。本实验推荐的方案是通过静脉途径给所有组注射2×10/kg体重的间充质干细胞，给药间隔为21天。通过检查视觉模拟量表、CADESI-4、皮肤组织病理学、血液学和生化参数、间充质干细胞的化脓作用以及表皮厚度来评估瘙痒程度。

结果

中度和重度组在表皮厚度减少方面存在显著差异。血液学、生化和体温参数保持在该物种的正常范围内，且无副作用。

结论

间充质干细胞减轻了特应性皮炎的临床症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0647/7521806/598263cd5571/JAVAR-7-554-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0647/7521806/b9f5d84d60d6/JAVAR-7-554-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0647/7521806/f29e6666c2d1/JAVAR-7-554-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0647/7521806/bbec66d7b9dc/JAVAR-7-554-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0647/7521806/91ee63496dc8/JAVAR-7-554-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0647/7521806/2de79f34a3ea/JAVAR-7-554-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0647/7521806/598263cd5571/JAVAR-7-554-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0647/7521806/b9f5d84d60d6/JAVAR-7-554-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0647/7521806/f29e6666c2d1/JAVAR-7-554-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0647/7521806/bbec66d7b9dc/JAVAR-7-554-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0647/7521806/91ee63496dc8/JAVAR-7-554-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0647/7521806/2de79f34a3ea/JAVAR-7-554-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0647/7521806/598263cd5571/JAVAR-7-554-g006.jpg

相似文献

1
Canine atopic dermatitis attenuated by mesenchymal stem cells.间充质干细胞减轻犬特应性皮炎。
J Adv Vet Anim Res. 2020 Sep 1;7(3):554-565. doi: 10.5455/javar.2020.g453. eCollection 2020 Sep.
2
Allogeneic adipose-derived mesenchymal stem cell therapy in dogs with refractory atopic dermatitis: clinical efficacy and safety.同种异体脂肪间充质干细胞治疗犬难治性特应性皮炎：临床疗效与安全性
Vet Rec. 2018 Dec 1;183(21):654. doi: 10.1136/vr.104867. Epub 2018 Aug 29.
3
A double-blinded placebo-controlled evaluation of adipose-derived mesenchymal stem cells in treatment of canine atopic dermatitis.脂肪间充质干细胞治疗犬特应性皮炎的双盲安慰剂对照评估
Vet Res Commun. 2022 Feb;46(1):251-260. doi: 10.1007/s11259-021-09853-9. Epub 2021 Oct 29.
4
Validation of the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4, a simplified severity scale for assessing skin lesions of atopic dermatitis in dogs.犬特应性皮炎范围和严重程度指数（CADESI）-4的验证，这是一种用于评估犬特应性皮炎皮肤病变的简化严重程度量表。
Vet Dermatol. 2014 Apr;25(2):77-85, e25. doi: 10.1111/vde.12107. Epub 2014 Jan 25.
5
Determination of CADESI-03 thresholds for increasing severity levels of canine atopic dermatitis.确定犬特应性皮炎严重程度增加时的CADESI-03阈值。
Vet Dermatol. 2008 Jun;19(3):115-9. doi: 10.1111/j.1365-3164.2008.00668.x.
6
Comparable efficacy of a topical 0.0584% hydrocortisone aceponate spray and oral ciclosporin in treating canine atopic dermatitis.外用0.0584%哈西奈德喷雾与口服环孢素治疗犬异位性皮炎的疗效相当。
Vet Dermatol. 2012 Feb;23(1):4-10, e1-2. doi: 10.1111/j.1365-3164.2011.00992.x. Epub 2011 Jul 1.
7
The effect of uterine-derived mesenchymal stromal cells for the treatment of canine atopic dermatitis: A pilot study.子宫源性间充质基质细胞治疗犬特应性皮炎的效果：一项初步研究。
Front Vet Sci. 2022 Sep 23;9:1011174. doi: 10.3389/fvets.2022.1011174. eCollection 2022.
8
Topical treatment with SPHINGOLIPIDS and GLYCOSAMINOGLYCANS for canine atopic dermatitis.针对犬特应性皮炎的鞘脂类和糖胺聚糖的局部治疗。
BMC Vet Res. 2020 Mar 20;16(1):92. doi: 10.1186/s12917-020-02306-6.
9
Evaluation of skin erythema severity by dermatoscopy in dogs with atopic dermatitis.应用皮肤镜评估犬特应性皮炎红斑严重程度。
Vet Dermatol. 2021 Apr;32(2):183-e46. doi: 10.1111/vde.12932. Epub 2021 Jan 6.
10
Development and validation of the Canine Atopic Dermatitis Lesion Index, a scale for the rapid scoring of lesion severity in canine atopic dermatitis.犬特应性皮炎皮损指数的开发与验证，一种用于快速评估犬特应性皮炎皮损严重程度的量表。
Vet Dermatol. 2012 Dec;23(6):515-e103. doi: 10.1111/j.1365-3164.2012.01113.x.

引用本文的文献

1
Therapeutic roles of natural and engineered mesenchymal stem cells and extracellular vesicles in atopic dermatitis.天然和工程化间充质干细胞及细胞外囊泡在特应性皮炎中的治疗作用
Regen Ther. 2025 Jun 4;30:123-135. doi: 10.1016/j.reth.2025.05.009. eCollection 2025 Dec.
2
Mesenchymal Stem Cells in Veterinary Medicine-Still Untapped Potential.兽医学中的间充质干细胞——仍未被开发的潜力
Animals (Basel). 2025 Apr 19;15(8):1175. doi: 10.3390/ani15081175.
3
Canine Mesenchymal Stromal Cell Exosomes: State-of-the-Art Characterization, Functional Analysis and Applications in Various Diseases.

本文引用的文献

1
Umbilical cord-derived mesenchymal stem cell extracts ameliorate atopic dermatitis in mice by reducing the T cell responses.脐带间充质干细胞提取物通过减少 T 细胞反应改善小鼠特应性皮炎。
Sci Rep. 2019 Apr 29;9(1):6623. doi: 10.1038/s41598-019-42964-7.
2
Allogeneic adipose-derived mesenchymal stem cell therapy in dogs with refractory atopic dermatitis: clinical efficacy and safety.同种异体脂肪间充质干细胞治疗犬难治性特应性皮炎：临床疗效与安全性
Vet Rec. 2018 Dec 1;183(21):654. doi: 10.1136/vr.104867. Epub 2018 Aug 29.
3
Exosomes derived from human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis.
犬间充质基质细胞外泌体：最新表征、功能分析及其在各种疾病中的应用
Vet Sci. 2024 Apr 25;11(5):187. doi: 10.3390/vetsci11050187.
4
Current Advances in Mesenchymal Stem Cell Therapies Applied to Wounds and Skin, Eye, and Neuromuscular Diseases in Companion Animals.间充质干细胞疗法在伴侣动物伤口、皮肤、眼睛及神经肌肉疾病中的应用现状进展
Animals (Basel). 2024 Apr 30;14(9):1363. doi: 10.3390/ani14091363.
5
Clinical efficacy of membrane-free stem cell extracts for the treatment of canine atopic dermatitis.无膜干细胞提取物治疗犬特应性皮炎的临床疗效
Vet Med (Praha). 2022 Jun 20;67(9):463-470. doi: 10.17221/136/2021-VETMED. eCollection 2022 Jun.
6
Canine amniotic membrane-derived mesenchymal stem cells ameliorate atopic dermatitis through regeneration and immunomodulation.犬类羊膜间充质干细胞通过再生和免疫调节改善特应性皮炎。
Vet Res Commun. 2023 Dec;47(4):2055-2070. doi: 10.1007/s11259-023-10155-5. Epub 2023 Jul 8.
7
Human Platelet-Rich Plasma Regulates Canine Mesenchymal Stem Cell Migration through Aquaporins.富血小板血浆通过水通道蛋白调节犬间充质干细胞迁移。
Stem Cells Int. 2023 May 15;2023:8344259. doi: 10.1155/2023/8344259. eCollection 2023.
8
The effect of uterine-derived mesenchymal stromal cells for the treatment of canine atopic dermatitis: A pilot study.子宫源性间充质基质细胞治疗犬特应性皮炎的效果：一项初步研究。
Front Vet Sci. 2022 Sep 23;9:1011174. doi: 10.3389/fvets.2022.1011174. eCollection 2022.
9
Manufacturing Mesenchymal Stromal Cells for the Treatment of Osteoarthritis in Canine Patients: Challenges and Recommendations.制造用于治疗犬类骨关节炎的间充质基质细胞：挑战与建议
Front Vet Sci. 2022 Jun 10;9:897150. doi: 10.3389/fvets.2022.897150. eCollection 2022.
人脂肪组织来源间充质干细胞衍生的外泌体缓解特应性皮炎。
Stem Cell Res Ther. 2018 Jul 11;9(1):187. doi: 10.1186/s13287-018-0939-5.
4
Human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis via regulation of B lymphocyte maturation.人脂肪组织来源的间充质干细胞通过调节B淋巴细胞成熟来缓解特应性皮炎。
Oncotarget. 2017 Jan 3;8(1):512-522. doi: 10.18632/oncotarget.13473.
5
A Prospective, Randomized, Masked, and Placebo-Controlled Efficacy Study of Intraarticular Allogeneic Adipose Stem Cells for the Treatment of Osteoarthritis in Dogs.关节内注射同种异体脂肪干细胞治疗犬骨关节炎的前瞻性、随机、盲法和安慰剂对照疗效研究
Front Vet Sci. 2016 Sep 16;3:81. doi: 10.3389/fvets.2016.00081. eCollection 2016.
6
Lymphocytic, cytokine and transcriptomic profiles in peripheral blood of dogs with atopic dermatitis.特应性皮炎犬外周血中的淋巴细胞、细胞因子和转录组谱
BMC Vet Res. 2016 Aug 23;12(1):174. doi: 10.1186/s12917-016-0805-6.
7
Early Activation of Th2/Th22 Inflammatory and Pruritogenic Pathways in Acute Canine Atopic Dermatitis Skin Lesions.急性犬特应性皮炎皮肤病变中Th2/Th22炎症和致痒途径的早期激活
J Invest Dermatol. 2016 Oct;136(10):1961-1969. doi: 10.1016/j.jid.2016.05.117. Epub 2016 Jun 21.
8
Clinical Trial of Human Umbilical Cord Blood-Derived Stem Cells for the Treatment of Moderate-to-Severe Atopic Dermatitis: Phase I/IIa Studies.人脐带血来源干细胞治疗中重度特应性皮炎的临床试验：I/IIa期研究
Stem Cells. 2017 Jan;35(1):248-255. doi: 10.1002/stem.2401. Epub 2016 Jun 28.
9
Safety evaluation of exosomes derived from human umbilical cord mesenchymal stromal cell.人脐带间充质基质细胞来源外泌体的安全性评估
Cytotherapy. 2016 Mar;18(3):413-22. doi: 10.1016/j.jcyt.2015.11.018.
10
Safety and efficacy of allogeneic adipose tissue-derived mesenchymal stem cells for treatment of dogs with inflammatory bowel disease: Endoscopic and histological outcomes.同种异体脂肪组织间充质干细胞治疗犬炎症性肠病的安全性和有效性：内镜及组织学结果
Vet J. 2015 Dec;206(3):391-7. doi: 10.1016/j.tvjl.2015.07.023. Epub 2015 Jul 23.