Department of Pathology, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkey.
Department of Biochemistry, Faculty of Veterinary Medicine, Kirikkale University, Kirikkale, Turkey.
Biotech Histochem. 2021 Aug;96(6):450-459. doi: 10.1080/10520295.2020.1818826. Epub 2020 Oct 2.
Skin and subcutaneous tissue tumors are the most common neoplasms in dogs. The most common sites of origin in dogs include digits, skin and the oral cavity including cheek and retromandibular area. We investigated canine squamous cell carcinoma (SCC) samples from 15 dogs and classified them histopathologically according to the degree of differentiation. bFGF, VEGF-C, TGF-β, PDGF-A, PDGF-C and PDGFR-α expressions were assessed using immunohistochemistry to determine the roles of growth factors during SCC. We found that TGF-β1 immunolabeling was elevated significantly compared to healthy controls in SCC originating from nailbeds, while expression of other growth factors did not change significantly. Our findings might explain the role of TGF-β1 in the infiltrative and malignant behavior of SCC originating from nailbeds.
皮肤和皮下组织肿瘤是犬最常见的肿瘤。犬最常见的起源部位包括指（趾）、皮肤和口腔，包括颊和下颌后区。我们研究了 15 只犬的犬鳞状细胞癌 (SCC) 样本，并根据分化程度进行了组织病理学分类。使用免疫组织化学评估 bFGF、VEGF-C、TGF-β、PDGF-A、PDGF-C 和 PDGFR-α 的表达，以确定生长因子在 SCC 中的作用。我们发现，起源于甲床的 SCC 中 TGF-β1 的免疫标记显著升高，而其他生长因子的表达没有显著变化。我们的发现可能解释了 TGF-β1 在起源于甲床的 SCC 的浸润和恶性行为中的作用。
