Heart Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Pediatr Cardiol. 2021 Feb;42(2):269-277. doi: 10.1007/s00246-020-02479-9. Epub 2020 Oct 2.
The objective of the study was to determine normal global left ventricular reference values for T1 and T2 in children. This is a retrospective study that included healthy subjects, age 5-19 years, who underwent CMR for the indication of pectus excavatum from 2018 to 2019. Linear regression models were used to determine associations of native T1 and T2 values to heart rate, age, and other CMR parameters. 102 patients with a mean age of 14.0 ± 2.4 years were included (range 5.4-18.8). 87 (85%) were males and 15 (15%) were females. The mean global T1 was 1018 ± 25 ms and the mean T2 was 53 ± 3 ms. T1 was negatively correlated with age (r = - 0.39, p < 0.001) and positively correlated with heart rate (r = 0.32, p < 0.001) by univariate analysis. Multivariable analysis showed that age and heart rate were independently associated with T1. T2 demonstrated a weak negative correlation with age (r = - 0.20, p = 0.047) and no correlation with heart rate. There was no difference in T1 (p = 0.23) or T2 (p = 0.52) between genders. This study reports normal pediatric T1 and T2 values at a 1.5 Tesla scanner. T1 was dependent on age and heart rate, while T2 was less dependent on age with no correlation with heart rate.
本研究旨在确定儿童整体左心室 T1 和 T2 的正常参考值。这是一项回顾性研究，纳入了 2018 年至 2019 年间因漏斗胸而行心脏磁共振（CMR）检查的健康受试者，年龄 5-19 岁。线性回归模型用于确定 T1 和 T2 值与心率、年龄和其他 CMR 参数的相关性。共纳入 102 例患者，平均年龄 14.0±2.4 岁（范围 5.4-18.8）。其中 87 例（85%）为男性，15 例（15%）为女性。整体 T1 平均值为 1018±25ms，T2 平均值为 53±3ms。T1 与年龄呈负相关（r=-0.39，p<0.001），与心率呈正相关（r=0.32，p<0.001），单因素分析结果如此。多因素分析显示，年龄和心率与 T1 独立相关。T2 与年龄呈弱负相关（r=-0.20，p=0.047），与心率无关。T1（p=0.23）或 T2（p=0.52）在性别间无差异。本研究报告了 1.5T 扫描仪下正常的儿科 T1 和 T2 值。T1 取决于年龄和心率，而 T2 受年龄影响较小，与心率无关。
