原发性颅内肿瘤的免疫生物学。II. 原发性脑肿瘤患者淋巴细胞亚群分析
Immunobiology of primary intracranial tumours. II. Analysis of lymphocyte subpopulations in patients with primary brain tumours.
作者信息
Brooks W H, Roszman T L, Mahaley M S, Woosley R E
出版信息
Clin Exp Immunol. 1977 Jul;29(1):61-6.
Abstract
Circulating peripheral blood lymphocyte subpopulations were analysed in patients with primary intracranial neoplasia. Patients with tumours of glial origin demonstrated a significant depletion of E-rosetting lymphocytes whereas the quantitative lymphocyte profiles of patients with non-glial brain tumours were normal. The number of immunoglobulin and Fe receptor-bearing cells was not significantly altered in any group of patients: however, the EAC-RFC subpopulation was increased in those with malignant gliomas. Two hypotheses are suggested to explain these observations: first, the presence of cross-reacting antibody between T cells and brain (glial) cells, and secondly, the proliferation of EAC-RFC in response to malignant degeneration.
摘要
对原发性颅内肿瘤患者的循环外周血淋巴细胞亚群进行了分析。胶质源性肿瘤患者的E花环形成淋巴细胞显著减少，而非胶质脑肿瘤患者的淋巴细胞定量分布正常。任何一组患者中免疫球蛋白和带有铁受体的细胞数量均无显著改变：然而，恶性胶质瘤患者的EAC-RFC亚群增加。提出了两种假说以解释这些观察结果：第一，T细胞与脑（胶质）细胞之间存在交叉反应抗体；第二，EAC-RFC因恶性变性而增殖。
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