Hu Ling, Li Ting, Yin Xiao-Ling, Zou Yi
Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Endocr Connect. 2020 Oct;9(9):933-938. doi: 10.1530/EC-20-0398.
The purpose of this study was to explore the prevalence of thyroid nodules (TN) and metabolic syndrome (MS) and to analyze the correlation between TN and the components of MS.
A total of 1526 subjects were divided into two groups: a TN group and a non-thyroid nodules (NTN) group. The height, weight, blood pressure, fasting blood glucose level, fasting plasma insulin level, serum lipid profile, uric acid level, serum thyroid-stimulating hormone (TSH) level, free triiodothyronine (FT3) level, and free thyroxine (FT4) level of each patient were measured. Insulin resistance (IR) was estimated by homeostasis model assessment of insulin resistance (HOMA-IR). Fatty liver and TN were detected by color Doppler ultrasonography.
(i) The overall prevalence of TN was 39.5%; it was significantly higher in women than in men (P < 0.01) and progressively increased with age in both sexes. (ii) The overall prevalence of MS was 25.6%; it was significantly higher in men than in women (P < 0.01) and progressively increased with age in both sexes. (iii) FT3 was significantly lower in the TN group than in the NTN group (P < 0.01). (iv) BMI, triglycerides, and HOMA-IR were higher in the TN group than in the NTN group (P < 0.05). (v) The existence of TN was significantly associated with overweight/obesity (OR = 1.03, 95% CI = 1.024-1.089), and with insulin resistance (IR) (OR = 1.98, 95% CI = 1.645-2.368), after adjusting for age and sex.
The prevalence of thyroid nodules and metabolic syndrome in the Nanchang area increases with age, and overweight/obesity and IR in patients are associated with thyroid nodules.
本研究旨在探讨甲状腺结节（TN）和代谢综合征（MS）的患病率，并分析TN与MS各组分之间的相关性。
总共1526名受试者被分为两组：甲状腺结节组和非甲状腺结节（NTN）组。测量每位患者的身高、体重、血压、空腹血糖水平、空腹血浆胰岛素水平、血脂谱、尿酸水平、血清促甲状腺激素（TSH）水平、游离三碘甲状腺原氨酸（FT3）水平和游离甲状腺素（FT4）水平。通过胰岛素抵抗稳态模型评估（HOMA-IR）估算胰岛素抵抗（IR）。采用彩色多普勒超声检测脂肪肝和TN。
（i）TN的总体患病率为39.5%；女性患病率显著高于男性（P<0.01），且在两性中均随年龄增长而逐渐升高。（ii）MS的总体患病率为25.6%；男性患病率显著高于女性（P<0.01），且在两性中均随年龄增长而逐渐升高。（iii）TN组的FT3显著低于NTN组（P<0.01）。（iv）TN组的BMI、甘油三酯和HOMA-IR高于NTN组（P<0.05）。（v）在校正年龄和性别后，TN的存在与超重/肥胖（OR = 1.03，95%CI = 1.024 - 1.089）以及胰岛素抵抗（IR）（OR = 1.98，95%CI = 1.645 - 2.368）显著相关。
南昌地区甲状腺结节和代谢综合征的患病率随年龄增长而增加，患者的超重/肥胖和IR与甲状腺结节有关。
