Beutler J A, Cardellina J H, McMahon J B, Boyd M R, Cragg G M
Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201.
J Nat Prod. 1992 Feb;55(2):207-13. doi: 10.1021/np50080a008.
The anti-HIV activity in the organic solvent extract of leaves of Buchenavia capitata was traced to a series of known flavonoid alkaloids, which represent a new chemotype for anti-HIV activity. The 13C-nmr assignments for this series of compounds have been revised. O-Demethylbuchenavianine [1] was the most active compound of the series but produced only moderate cytoprotective effects against HIV in cultured human lymphoblastoid (CEM-SS) cells. Compound 1 was cytotoxic also in the NCI human disease-oriented in vitro tumor screening panel and produced a pattern of modest differential cellular sensitivity.
布氏头状木叶片的有机溶剂提取物中的抗HIV活性可追溯到一系列已知的黄酮生物碱，它们代表了一种抗HIV活性的新化学类型。已对该系列化合物的13C-核磁共振归属进行了修订。O-去甲基布氏头状木碱[1]是该系列中活性最强的化合物，但在培养的人淋巴母细胞（CEM-SS）中对HIV仅产生中等程度的细胞保护作用。化合物1在NCI面向人类疾病的体外肿瘤筛选面板中也具有细胞毒性，并产生了适度的细胞敏感性差异模式。
